The author of 《Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines》 were Kaminski, James J.; Bristol, James A.; Puchalski, Chester; Lovey, Raymond G.; Elliott, Arthur J.; Guzik, Henry; Solomon, Daniel M.; Conn, David J.; Domalski, Martin S.. And the article was published in Journal of Medicinal Chemistry in 1985. Computed Properties of C8H8N2O The author mentioned the following in the article:
The title compounds (I; R = H, OH, CHO, PhO, (un)substituted benzyloxy, PhCH2NH, etc.; R1 = H, or PhCH2CH2; R2 = H, Me, Et, CHMe2; R3 = H, Me, CO2H, CO2Et, CN, CH2CN, etc.), prepared in general by condensation of substituted 2-aminopyridines with α-halocarbonyls, were evaluated for gastric antisecretory activity in the pylorus-ligated rat and inhibition of histamine-stimulated gastric secretion in the adult dog and gastric cytoprotective activity in the rat. In the pylorus-ligated rat, I were given at 40 mg/kg i.p., at time of ligation and reduction in acid output was measured after 4 h, and in the dog I was 1st administered i.v. 0.1-5 mg/kg and reduction in the acid output relative to nondrug-treated control value in the same animal was measured. For gastric cytoprotective activity I was given orally 1-30 mg/kg 30 min before oral administration of absolute EtOH, and the effect against EtOH-induced lesions was determined after 1 h. The results show that I are not histamine (H2) receptor antagonists nor are they prostaglandin analogs, yet they exhibit both gastric antisecretory and cytoprotective properties. The mechanism of gastric antisecretory activity may involve inhibition of H+/K+-ATPase. 3-(Cyanomethyl)-2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine (I); R = PhCH2O, R1 = H, R2 = Me, R3 = CH2CN)(SCH 28080) [76081-98-6] was selected for clin. evaluation. Structure-activity relations are discussed. The results came from multiple reactions, including the reaction of 2-Methylimidazo[1,2-a]pyridin-8-ol(cas: 79707-11-2Computed Properties of C8H8N2O)
2-Methylimidazo[1,2-a]pyridin-8-ol(cas: 79707-11-2) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. Computed Properties of C8H8N2O In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem