Garbaccio, Robert M.; Brnardic, Edward J.; Fraley, Mark E.; Hartman, George D.; Hutson, Pete H.; O’Brien, Julie A.; Magliaro, Brian C.; Uslaner, Jason M.; Huszar, Sarah L.; Fillgrove, Kerry L.; Small, James H.; Tang, Cuyue; Kuo, Yuhsin; Jacobson, Marlene A. published the artcile< Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor>, Product Details of C8H4ClN3, the main research area is oxazolo benzimidazole derivative preparation allosteric modulator mGluR2 receptor antipsychotic; GPCR; Oxazolobenzimidazoles; allosteric modulators; hyperlocomotion model; metabotropic glutamate 2 receptor; schizophrenia.
Novel oxazolobenzimidazoles are described as potent and selective pos. allosteric modulators of the metabotropic glutamate receptor 2. The discovery of this class and optimization of its phys. and pharmacokinetic properties led to the identification of potent and orally bioavailable compounds (20 and 21) as advanced leads. Compound 20 (TBPCOB) was shown to have robust activity in a PCP-induced hyperlocomotion model in rat, an assay responsive to clin. antipsychotic treatments for schizophrenia.
ACS Medicinal Chemistry Letters published new progress about Antipsychotics. 401567-00-8 belongs to class imidazoles-derivatives, and the molecular formula is C8H4ClN3, Product Details of C8H4ClN3.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem