Electric Literature of C7H7N3In 2020 ,《Copper-Catalyzed Synthesis of Trinuclear N-Fused Hybrid Scaffolds by Double C(sp2)-N Bond Formation between 2-(2-Bromoaryl)indoles and 2-Aminoazoles》 appeared in European Journal of Organic Chemistry. The author of the article were Diep, Thi Duyen; Pham, Duy Quang Dao; Ho, Son Long; Cho, Chan Sik. The article conveys some information:
2-(2-Bromoaryl)indoles react with 2-aminoazoles by microwave irradiation in DMF in the presence of a catalytic amount of CuI and a base to produce trinuclear N-fused hybrid scaffolds, benzo[4,5]imidazo[1,2-a]indolo[1,2-c]quinazolines and imidazo[1,2-a]indolo[1,2-c]quinazolines in moderate to good yields [e.g., 2-(2-bromophenyl)indole + 2-aminobenzimidazole → I (74%) in presence of CuI and K3PO4 in DMF]. The reaction seems to proceed via copper-catalyzed C(sp2)-N coupling and subsequent intramol. cyclocondensation accompanied by ammonia evolution. Complete regioselective C-N cyclization is observed with the reaction of 2-(2-bromophenyl)indole with 2-aminoazoles. In the part of experimental materials, we found many familiar compounds, such as 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Electric Literature of C7H7N3)
1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Electric Literature of C7H7N3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem