Devine, Shane M.’s team published research in European Journal of Medicinal Chemistry in 2021 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.SDS of cas: 934-32-7

Devine, Shane M.; Challis, Matthew P.; Kigotho, Jomo K.; Siddiqui, Ghizal; De Paoli, Amanda; MacRaild, Christopher A.; Avery, Vicky M.; Creek, Darren J.; Norton, Raymond S.; Scammells, Peter J. published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Discovery and development of 2-aminobenzimidazoles as potent antimalarials》.SDS of cas: 934-32-7 The article contains the following contents:

The design, synthesis and antimalarial activity of a series of 2-aminobenzimidazoles I [R = H, NH2, NHEt, NHBn, etc.; Ar = 2-HOC6H4, 2-NH2C6H4, benzofuran-7-yl, etc.], featuring a phenol moiety that was crucial to the pharmacophore. Two potent mols. exhibited IC50 values against P. falciparum 3D7 strain of 42 ± 4 I [R = NH2; Ar = 5-Me-2-HOC6H3] and 43 ± 2 nM [R = NH2; Ar = 5-MeO-2-HOC6H3] and high potency against strains resistant to chloroquine (Dd2), artemisinin (Cam3.IIC580Y) and PfATP4 inhibitors (SJ557733), while demonstrating no cytotoxicity against human cells (HEK293, IC50 > 50μM). The most potent mol., possessing a 4,5-di-Me substituted phenol I [R = NH2; Ar = 4,5-(MeO)2-2-HOC6H2] displayed an IC50 value of 6.4 ± 0.5 nM against P. falciparum 3D7, representing a 12-fold increase in activity from the parent mol. The 2-aminobenzimidazoles containing a N1-substituted phenol represented a new class of mols. that had high potency in vitro against P. falciparum malaria and low cytotoxicity. They possessed attractive pharmaceutical properties, including low mol. weight, high ligand efficiency, high solubility, synthetic tractability and low in vitro clearance in human liver microsomes. After reading the article, we found that the author used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7SDS of cas: 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.SDS of cas: 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem