Product Details of 16681-56-4In 2006 ,《Photochemical intramolecular aromatic substitutions of the imidazol-2-yl radical are superior to those mediated by Bu3SnH》 appeared in Organic & Biomolecular Chemistry. The author of the article were Clyne, Mairead A.; Aldabbagh, Fawaz. The article conveys some information:
Six-membered photochem. cyclizations of 2-iodo-N-(2-arylethyl)imidazoles proceeded regioselectively in higher yields than the equivalent tin hydride-mediated reactions. E.g., photochem. cyclizations of 2-iodo-N-(2-arylethyl)imidazole I gave 70% 5,6-dihydroimidazo[2,1-a]isoquinoline II. The decrease in yield of cyclization products, 5,6-dihydroimidazo[2,1-a]isoquinolines containing strongly deactivating substituents on the aryl ring confirmed the electrophilic nature of the σ-imidazol-2-yl radicals. The seven-membered cyclization was only successful under photochem. conditions, as radical reduction occurred with tin hydride. Nitration of 5,6-dihydroimidazo[2,1-a]isoquinolines with nitric/sulfuric acid occurred at the 2- and 8-positions. In the experiment, the researchers used many compounds, for example, 2-Bromo-1H-imidazole(cas: 16681-56-4Product Details of 16681-56-4)
2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Product Details of 16681-56-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem