Synthetic Route of C27H38AuClN2On September 20, 2021 ,《Continuous Flow Synthesis of [Au(NHC)(Aryl)] (NHC = N-Heterocyclic Carbene) Complexes》 was published in Chemistry – A European Journal. The article was written by Cauwenbergh, Thibault; Tzouras, Nikolaos V.; Scattolin, Thomas; Bhandary, Subhrajyoti; Simoens, Andreas; Van Hecke, Kristof; Stevens, Christian V.; Nolan, Steven P.. The article contains the following contents:
The use of weak and inexpensive bases has recently opened promising perspectives towards the simpler and more sustainable synthesis of Au(I)-aryl complexes with valuable applications in catalysis, medicinal chem., and materials science. In recent years, continuous manufacturing has shown to be a reliable partner in establishing sustainable and controlled process scalability. Herein, the first continuous flow synthesis of a range of Au(I)-aryl starting from widely available boronic acids and various [Au(NHC)Cl] (NHC = N-heterocyclic carbene) complexes in unprecedentedly short reaction times and high yields is reported. Successful synthesis of previously non- or poorly accessible complexes exposed fascinating reactivity patterns. Via a gram-scale synthesis, convenient process scalability of the developed protocol was showcased. The results came from multiple reactions, including the reaction of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Synthetic Route of C27H38AuClN2)
Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Synthetic Route of C27H38AuClN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem