Ishikawa, Ryo; Yasuda, Mizuho; Sasaki, Shogo; Ma, Yue; Nagasawa, Kazuo; Tera, Masayuki published the artcile< Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease>, Synthetic Route of 452-06-2, the main research area is stabilization G quadruplex S1 nuclease ligand binding.
The extent of thermodn. stabilization of telomeric G-quadruplex (G4) by isomers of G4 ligand L2H2-6OTD, a telomestatin analog, is inversely correlated with susceptibility to S1 nuclease. L2H2-6OTD facilitated the S1 nuclease activities through the base flipping in G4, unlike the conventional role of G4 ligands which inhibit the protein binding to DNA/RNA upon ligand interactions.
Chemical Communications (Cambridge, United Kingdom) published new progress about Enzyme functional sites, ligand-binding. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Synthetic Route of 452-06-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem