Asoh, Kohsuke; Kohchi, Masami; Hyoudoh, Ikumi; Ohtsuka, Tatsuo; Masubuchi, Miyako; Kawasaki, Kenichi; Ebiike, Hirosato; Shiratori, Yasuhiko; Fukami, Takaaki A.; Kondoh, Osamu; Tsukaguchi, Toshiyuki; Ishii, Nobuya; Aoki, Yuko; Shimma, Nobuo; Sakaitani, Masahiro published the artcile< Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors>, Name: 5-Bromo-1-methyl-1H-imidazole, the main research area is benzofuran imidazolyl preparation farnesyltransferase inhibitor.
A series of imidazolylbenzofuran-based farnesyltransferase inhibitors have been designed and synthesized as antitumor agents. Among them, I showed the most potent enzyme inhibitory activity (IC50 = 1.1 nM) and antitumor activity in human cancer xenografts in mice.
Bioorganic & Medicinal Chemistry Letters published new progress about Crystal structure. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Name: 5-Bromo-1-methyl-1H-imidazole.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem