Wenzel, Anna G.; Grubbs, Robert H. published their research in Journal of the American Chemical Society on December 20 ,2006. The article was titled 《Ruthenium Metallacycles Derived from 14-Electron Complexes. New Insights into Olefin Metathesis Intermediates》.HPLC of Formula: 866926-59-2 The article contains the following contents:
Ru(IV) metallacycles derived from both ethylene and propene are reported. The propene-derived metallacycles represent the 1st observed examples of substituted ruthenacyclobutanes and offer new insight into the preferred stereochem. orientation about metathesis intermediates. The authors showed evidence supporting the bottom-face orientation of Ru(IV) metallacycles derived from both ethylene and propene. The unsym. disubstituted 1-(2,6-diisopropylphenyl)-3-(2,4,6-trimethylphenyl)-4,5-dihydroimidazolinium chloride ([H2ImesiPrH]+Cl-) and the ruthenium carbene complex [(H2ImesiPr)Ru(:CHPCy3)(Cl)2]+[BF4]- were prepared The mol. structure of the ruthenium carbene complex was determined by x-ray crystallog. Reaction of the ruthenium carbene complex with ethylene gave a ruthenacyclobutane possessing an unsym. N-heterocyclic carbene (NHC) ligand. The complex was studied to ascertain the dynamics of the NHC relative to the metallacycle ring. Ruthenacyclobutanes studied possess exchange cross-peaks between the α- and β-positions in the 2-dimensional NMR, indicating a dynamic structure. The ruthenacyclobutanes derived from ethylene and propene proceed through nonproductive metallacycle formations/cycloreversions prior to olefin exchange. The implications of these results to the mechanism of Ru-catalyzed olefin metathesis are discussed. In the part of experimental materials, we found many familiar compounds, such as 1-(2,6-Diisopropylphenyl)-3-mesityl-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 866926-59-2HPLC of Formula: 866926-59-2)
1-(2,6-Diisopropylphenyl)-3-mesityl-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 866926-59-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.HPLC of Formula: 866926-59-2 Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem