Recommanded Product: 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazoleOn November 1, 2004 ,《Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Terzioglu, Nalan; van Rijn, Richard M.; Bakker, Remko A.; De Esch, Iwan J. P.; Leurs, Rob. The article conveys some information:
The structure-activity relationship for a series of ligands structurally related to the recently identified (5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone (I) as histamine H4 receptor (H4R) antagonists, is reported. Furthermore, related benzimidazoles was identified as lead compounds for the H4R. The ligands have been evaluated by radioligand displacement studies and functional assays for their interaction with both the human histamine H3 and H4 receptors and exhibit pKi values up to 7.5 at the human H4R. The experimental process involved the reaction of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Recommanded Product: 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole)
5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Recommanded Product: 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem