Tanis, Virginia M.; Venkatesan, Hariharan; Cummings, Maxwell D.; Albers, Michael; Kent Barbay, J.; Herman, Krystal; Kummer, David A.; Milligan, Cynthia; Nelen, Marina I.; Nishimura, Rachel; Schlueter, Thomas; Scott, Brian; Spurlino, John; Wolin, Ronald; Woods, Craig; Xue, Xiaohua; Edwards, James P.; Fourie, Anne M.; Leonard, Kristi published the artcile< 3-Substituted Quinolines as RORγt Inverse Agonists>, Quality Control of 1003-21-0, the main research area is quinoline derivative preparation ROR gamma t inverse agonist SAR; IL-17; Inverse agonist; RORγt; Retinoic acid-related orphan nuclear receptor gamma t; Th17.
We have previously reported the syntheses of a series of 3,6-disubstituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). These mols. are potent binders but are high mol. weight and they exhibited poor solubility at pH 2 and pH 7. This manuscript details our efforts at improving phys. chem. properties for this series of compounds by increasing the diversity at the 3-position (i.e. introducing heteroatoms and lowering the mol. weight). These efforts have led to mols. which are potent binders with improved solubility
Bioorganic & Medicinal Chemistry Letters published new progress about Drug design. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Quality Control of 1003-21-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem