In 2018,Research on Chemical Intermediates included an article by Srikrishna, Devulapally; Dubey, Pramod Kumar. Electric Literature of C7H5ClN2. The article was titled 《Synthesis of novel substituted 3-(4-((1H-benzo[d]imidazol-2-ylthio)methyl)-1-phenyl-1H-pyrazol-3-yl)-2H-chromen-2-ones: various approaches》. The information in the text is summarized as follows:
Considering benzimidazole as a privileged structure for developing probes of impressive pharmacol. potentials, some new coumarin and pyrazole conjugates of benzimidazoles I (R = Me, Et, Bn; X = H, OMe) were synthesized with a sulfur linkage. Thus, 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde was prepared starting from simple salicylaldehyde which has been used as an important synthon and incorporated in a series of structural manipulations to obtain various pharmacophoric motif conjugates I (R = H, Me, Et, Bn) in fair yields. A facile and stepwise method has been developed for the synthesis of all these compounds in various approaches, which also involves sub-sequences. In addition to this study using 2-Chloro-1H-benzo[d]imidazole, there are many other studies that have used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Electric Literature of C7H5ClN2) was used in this study.
2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Electric Literature of C7H5ClN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem