Electric Literature of C3H5N3In 2017 ,《Pyridine-pyrimidine amides that prevent HGF-induced epithelial scattering by two distinct mechanisms》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Siddiqui-Jain, Adam; Hoj, Jacob P.; Hargiss, J. Blade; Hoj, Taylor H.; Payne, Carter J.; Ritchie, Collin A.; Herron, Steven R.; Quinn, Colette; Schuler, Jeffrey T.; Hansen, Marc D. H.. The article conveys some information:
Stimulation of cultured epithelial cells with scatter factor/hepatocyte growth factor (HGF) results in individual cells detaching and assuming a migratory and invasive phenotype. Epithelial scattering recapitulates cancer progression and studies have implicated HGF signaling as a driver of cancer metastasis. Inhibitors of HGF signaling have been proposed to act as anti-cancer agents. The authors previously screened a small mol. library for compounds that block HGF-induced epithelial scattering. Most hits identified in this screen exhibit anti-mitotic properties. Here the authors assess the biol. mechanism of a compound that blocks HGF-induced scattering with limited anti-mitotic activity. Analogs of this compound have one of two distinct activities: inhibiting either cell migration or cell proliferation with cell cycle arrest in G2/M. Each activity bears unique structure-activity relationships. The mechanism of action of anti-mitotic compounds is by inhibition of microtubule polymerization; these compounds entropically and enthalpically bind tubulin in the colchicine binding site, generating a conformational change in the tubulin dimer.1H-Imidazol-2-amine(cas: 7720-39-0Electric Literature of C3H5N3) was used in this study.
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C3H5N3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem