《Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors》 was published in JBIC, Journal of Biological Inorganic Chemistry in 2020. These research results belong to Legina, Maria S.; Nogueira, Juan J.; Kandioller, Wolfgang; Jakupec, Michael A.; Gonzalez, Leticia; Keppler, Bernhard K.. HPLC of Formula: 616-47-7 The article mentions the following:
Abstract: Topoisomerase IIα (topo2α) is an essential nuclear enzyme involved in DNA replication, transcription, recombination, chromosome condensation, and highly expressed in many tumors. Thus, topo2α-targeting has become a very efficient and well-established anticancer strategy. Herein, we investigate the cytotoxic and DNA-damaging activity of thiomaltol-containing ruthenium-, osmium-, rhodium- and iridium-based organometallic complexes in human mammary carcinoma cell lines by means of several biol. assays, including knockdown of topo2α expression levels by RNA interference. Results suggest that inhibition of topo2α is a key process in the cytotoxic mechanism for some of the compounds, whereas direct induction of DNA double-strand breaks or other DNA damage is mostly rather minor. In addition, mol. modeling studies performed for two of the compounds (with Ru(II) as the metal center) evinces that these complexes are able to access the DNA-binding pocket of the enzyme, where the hydrophilic environment favors the interaction with highly polar complexes. These findings substantiate the potential of these compounds for application as antitumor metallopharmaceuticals. Graphic abstract: [graphic not available: see fulltext] In the experiment, the researchers used 1-Methyl-1H-imidazole(cas: 616-47-7HPLC of Formula: 616-47-7)
1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.HPLC of Formula: 616-47-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem