The author of 《Synthesis of novel histamine H4 receptor antagonists》 were Lane, Charlotte A. L.; Hay, Duncan; Mowbray, Charles E.; Paradowski, Michael; Selby, Matthew D.; Swain, Nigel A.; Williams, David H.. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2012. Formula: C8H4Cl4N2 The author mentioned the following in the article:
This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound I was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution. The experimental process involved the reaction of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Formula: C8H4Cl4N2)
5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Formula: C8H4Cl4N2 Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem