In 1985,Catalan, Javier; Menendez, Margarita; Elguero, Jose published 《On the relationships between basicity and acidity in azoles》.Bulletin de la Societe Chimique de France published the findings.Recommanded Product: 16681-56-4 The information in the text is summarized as follows:
A linear relation between both acidic and basic pKa values is shown for a large collection of imidazoles, benzimidazoles, 1,2,4-triazoles and tetrazoles. Surprisingly, pyrazoles fall on a parallel line, separated from the preceding one by 3.1 pKa units; pyrazoles, and probably 1,2,3-triazoles, are less basic than the other azoles. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-1H-imidazole(cas: 16681-56-4Recommanded Product: 16681-56-4)
2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Recommanded Product: 16681-56-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem