In 2020,Chemical Communications (Cambridge, United Kingdom) included an article by Wei, Yi-Ming; Ma, Xiao-Di; Wang, Lei; Duan, Xin-Fang. Application of 258278-25-0. The article was titled 《Iron-catalyzed stereospecific arylation of enol tosylates using Grignard reagents》. The information in the text is summarized as follows:
The stereospecific Fe-catalyzed arylation of enol tosylates with Grignard reagents was reported for the synthesis of Z- and E- tri/tetrasubstituted acrylates (Ar)(R)C=C(CO2R1)(R2) [R = Me, i-Pr, Ph, etc.; R1 = Me, Et; R2 = H, Me, Ph; Ar = Ph, 2-CNC6H4, 2-thienyl, etc.]. Various tri- or tetrasubstituted Z or E-enol tosylates of β-keto esters were arylated using common and Knochel-type Grignard reagents with complete stereofidelity. The precursors for Z/E-zimelidine, tamoxifen and other bioactive compounds were facilely prepared without precious and toxic transition metals. The results came from multiple reactions, including the reaction of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0Application of 258278-25-0)
1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0) has been employed in an efficient, one-pot synthesis of N-heterocyclic carbene-allylpalladium complexes.Application of 258278-25-0In addition, it can efficiently catalyze the Suzuki-Miyaura coupling of aryl chlorides with aryl boronic acids.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem