Application In Synthesis of 2-Bromo-1H-imidazoleIn 1982 ,《Radiosensitization by non-nitro compounds》 appeared in International Journal of Radiation Oncology, Biology, Physics. The author of the article were Wardman, P.; Anderson, R. F.; Hodgkiss, R. J.; Parrick, J.; Smithen, C. E.; Wallace, R. G.; Watts, M. E.. The article conveys some information:
The effects of non-nitro compounds on the radiosensitivity of hypoxic Chinese hamster V79-379A or Escherichia coli AB 1157 cells in vitro are outlined. Imidazole derivatives substituted with several alternative electron-withdrawing groups are described; the dicyanovinyl function conferred considerable radiosensitizing activity. 2,4,5-Tribromoimidazole and 2,4-DNP may show unusual radiosensitizing activity because of interference with oxidative phosphorylation. Attempts to influence radiosensitivity by compounds potentially capable of depleting intracellular SH groups are also described.2-Bromo-1H-imidazole(cas: 16681-56-4Application In Synthesis of 2-Bromo-1H-imidazole) was used in this study.
2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Application In Synthesis of 2-Bromo-1H-imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem