Sreeja, S.; Anton, Smith A.; Madan, S.; Sunilkumar, D.; Vani, V. published their research in International Journal of Pharmacy and Pharmaceutical Sciences in 2021. The article was titled 《Computational molecular modelling of 2-aminobenzimidazole derivatives: strong successor of hypoglycaemic agent》.Application of 934-32-7 The article contains the following contents:
The present study was aimed to design different analogs of 2-aminobenzimidazole and find the binding ability by Insilico method. Various softwares like Chemsketch, Molinspiration, PASS, and Discovery studio were used to design the proposed derivatives Evaluation of binding activity against different receptors was detected and checked their physicochem. properties for binding. In this study, we designed different analogs of 2-aminobenzimidazole into a ligand having a binding affinity with alpha-glucosidase, Dipeptidyl-peptidase 4 (DPP4), Peroximase proliferator-activated receptor gamma (PPARγ), and Insulin-like growth factor 1 (IGF-1) receptor. The designed ten derivatives showed a significant binding capacity to the concerned receptors. These results pointed that the designed proposed derivatives promising hypoglycemic activity. In the part of experimental materials, we found many familiar compounds, such as 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Application of 934-32-7)
1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Application of 934-32-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem