《N-Propargylation and Copper(I)-Catalyzed Azide-Alkyne Cycloaddition as a Convenient Strategy for Directed Post-Synthetic Modification of 4-Oxo-1,4-Dihydrocinnoline Derivatives》 was written by Mikhaylov, Vladimir N.; Pavlov, Artem O.; Ogorodnov, Yaroslav V.; Spiridonova, Dar’ya V.; Sorokoumov, Viktor N.; Balova, Irina A.. Quality Control of 1,3-Dimesityl-1H-imidazol-3-ium chloride And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2020. The article conveys some information:
4-Oxo-1,4-dihydrocinnoline derivatives as promising inhibitors of protein tyrosine phosphatase 1B were subjected to post-synthetic modification via a sequence of propargylation and copper(I)-catalyzed azide-alkyne cycloaddition reactions. The propargylation of 4-oxo- 1,4-dihydrocinnolines with propargyl bromide in the presence of various bases proceeded regioselectively at the cinnolinone N-1 atom. In the cycloaddition reaction of N-propargylcinnolinones and benzyl azide, the highest catalytic activity of copper(I) N-heterocyclic carbene complex [(IMes)Cu(Br,I)] (IMes = 1,3-bis-(2,4,6-trimethylphenyl)imidazol-2-ylidene) was observed, compared to [(IMes)CuCl], [(IPr)Cu(Cl,Br,I)] (IPr = 1,3-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene), and CuI. In addition to this study using 1,3-Dimesityl-1H-imidazol-3-ium chloride, there are many other studies that have used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Quality Control of 1,3-Dimesityl-1H-imidazol-3-ium chloride) was used in this study.
1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Quality Control of 1,3-Dimesityl-1H-imidazol-3-ium chloride
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem