Formula: C3H5N3In 2020 ,《Activity-directed expansion of a series of antibacterial agents》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Leggott, Abbie; Clarke, Justin E.; Chow, Shiao; Warriner, Stuart L.; O’Neill, Alex J.; Nelson, Adam. The article conveys some information:
The feasibility of using activity-directed synthesis to drive antibacterial discovery was investigated. An array of 220 Pd-catalyzed microscale reactions was executed, and the crude product mixtures were evaluated for activity against Staphylococcus aureus. Scale-up of the hit reactions, purification and evaluation, enabled expansion of a class of antibacterial quinazolinones. The novel antibacterials had MICs from 0.016μg mL-1 (i.e. 38 nM) to 2-4μg mL-1 against S. aureus ATCC29213. After reading the article, we found that the author used 1H-Imidazol-2-amine(cas: 7720-39-0Formula: C3H5N3)
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Formula: C3H5N3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem