《2-(Trihalomethyl)benzazoles. I. Formation》 was published in Journal of the Chemical Society [Section] C: Organic in 1967. These research results belong to Holan, George; Samuel, Eva L.; Ennis, B. C.; Hinde, Ronald W.. Related Products of 3584-66-5 The article mentions the following:
Methods of preparation of 2-(trihalomethyl)benzimidazoles, -benzothiazoles, and -benzoxazoles were investigated. The reaction of the mono salts of o-phenylenediamines, o-aminophenols, and o-aminothiophenols with trichloroacetonitrile or trichloroacetimidate esters affords 2-(trichloromethyl)-substituted benzimidazoles, benzoaxazoles, and benzothiazoles. This method was extended to the preparation of 2-(trichloromethyl)-2-imidazolines. A general method of preparation of 2,2′-bibenzimidazolyl (I) derivatives is also described. 20 references. In the experiment, the researchers used 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Related Products of 3584-66-5)
5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. Related Products of 3584-66-5 In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem