Gupta, Radhey S. published an article on February 27 ,1987. The article was titled 《Identification of 2-benzimidazolylurea as a new antimitotic compound based on cross resistance studies with nocodazole resistant mutants of CHO cells》, and you may find the article in Biochemical and Biophysical Research Communications.Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole The information in the text is summarized as follows:
The cross-resistance patterns of a set of nocodazole [31430-18-9]-resistant (NocR) and podophyllotoxin [518-28-5]-resistant (PodR) mutants of Chinese hamster ovary cells, which exhibit highly-specific cross-resistance toward compounds that show nocodazole-like antimitotic activity, towards a large number of benzimidazole derivatives was examined Of the various compounds examined, the NocR and the PodR mutants were found to exhibit increased cross-resistance towards only 2-benzimidazolylurea [24370-25-0], indicating that this compound may possess similar biol. activity as nocodazole. The nocodazole-like antimitotic activity of 2-benzimidazolylurea was confirmed by its ability to block cells in mitosis, and by its competition of [3H]podophyllotoxin binding to microtubule proteins in cell extracts The nocodazole-like behavior of 2-benzimidazolylurea and lack of similar activity in other benzimidazole derivatives examined, provides valuable information regarding structural features that are required for this type of biol. activity. After reading the article, we found that the author used 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole)
5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem