Carter, S. R.’s team published research in Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) in 2002 | CAS: 16681-56-4

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Product Details of 16681-56-4

In 2002,Carter, S. R.; Rimmer, S. published 《Smart hyperbranched polymers for the purification of biomolecules》.Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published the findings.Product Details of 16681-56-4 The information in the text is summarized as follows:

The use of a SMART polymer such as polyNIPAM allows for a hyperbranched structure to respond to small changes in temperature, pH or ionic strength. A hyperbranched SMART polymer with ligands situated at chain-ends should allow for multi-point attachment to biomacromols. in response to a change in an external stimulus. The hyperbranched poly-NIPAM polymers, where the chain termini are functionalized with an imidazole group, was prepared using the radical addition fragmentation termination (RAFT) methodol. The RAFT technique allows for control over the degree of branching by varying the proportion of dithionate ester to NIPAM. The RAFT agent 4-vinylbenzylimidazole dithioate was synthesized from 4(5)-imidazoledithioic acid and 4-vinylbenzyl chloride in DMF solvent using cesium carbonate as base. The pure product was achieved in moderate yield (27%) by repeated column chromatog. using silica and alumina sorbents. The synthetic procedure developed allowed the production of several series of macro-ligands with various mol. sizes, distances between ligands and spatial arrangement of ligands. The polymers can form multi-point attachments to specific sites on a biomacromol. so that changes in these mol. parameters will be a means of selectively targeting particular biomols. In the experiment, the researchers used 2-Bromo-1H-imidazole(cas: 16681-56-4Product Details of 16681-56-4)

2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Product Details of 16681-56-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem