Zheng, Yangyang; Hong, Kunqiang; Wang, Baowei; Liu, Dingyu; Chen, Tao; Wang, Zhiwen published the artcile< Genetic Diversity for Accelerating Microbial Adaptive Laboratory Evolution>, Application In Synthesis of 452-06-2, the main research area is review accelerating microbial adaptive laboratory genetic diversity; adaptive laboratory evolution; genetic diversity; genome editing; mutant library.
A review. Adaptive laboratory evolution (ALE) is a widely used and highly effective tool for improving microbial phenotypes and investigating the evolutionary roots of biol. phenomena. Serving as the raw materials of evolution, mutations have been extensively utilized to increase the chances of engineering mols. or microbes with tailor-made functions. The generation of genetic diversity is therefore a core technol. for accelerating ALE, and a high-quality mutant library is crucial to its success. Because of its importance, technologies for generating genetic diversity have undergone rapid development in recent years. Here, we review the existing techniques for the construction of mutant libraries, briefly introduce their mechanisms and applications, discuss ongoing and emerging efforts to apply engineering technologies in the construction of mutant libraries, and suggest future perspectives for library construction.
ACS Synthetic Biology published new progress about Alkylating agents. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Application In Synthesis of 452-06-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem