Subramani, Vinod Kumar; Ravichandran, Subramaniyam; Bansal, Varun; Kim, Kyeong Kyu published the artcile< Chemical-induced formation of BZ-junction with base extrusion>, Recommanded Product: 7H-Purin-2-amine, the main research area is spermine ethanol methanol cobalt sodium perchlorate; 2-Aminopurine; BZ-Junction; Base-extrusion; Z-DNA; Z-DNA junction; Z-inducer.
The crystal structure of BZ-junction reveals that left-handed Z-DNA stabilized by Z-DNA binding domain (Zα) is continuously stacked to right-handed B-DNA with AT bases’ extrusion in the junction site. However, this structure might not fully represent the BZ-junction in solution due to the possibility of the junction formation either by crystal packing or Zα interaction. Therefore, we investigated BZ-junction in solution with chem. Z-DNA inducers using CD and 2-aminopurine base-extrusion assay. We confirmed the formation of Z-DNA and BZ-junction with base-extrusion by chem. Z-DNA inducers. However, neither typical Z-DNA nor base-extrusion could be detected with some inducers such as spermine, suggesting that the energy barrier for the formation of the BZ junction might vary depending on the Z-DNA induction conditions.
Biochemical and Biophysical Research Communications published new progress about Crystal structure. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Recommanded Product: 7H-Purin-2-amine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem