Kuznetsova, A. A.; Kladova, O. A.; Barthes, Nicolas P. F.; Michel, Benoit Y.; Burger, Alain; Fedorova, O. S.; Kuznetsov, N. A. published the artcile< Comparative Analysis of Nucleotide Fluorescent Analogs for Registration of DNA Conformational Changes Induced by Interaction with Formamidopyrimidine-DNA Glycosylase Fpg>, SDS of cas: 452-06-2, the main research area is Escherichia DNA Fpg aPu 3HC Cpy tC0.
Abstract: DNA-substrates containing fluorescent DNA base analogs are widely used to study protein-nucleic acid interactions. In the case of DNA-recognizing enzymes, this approach allows one to register conformational changes in DNA during the formation of enzyme-substrate complexes. An important part of such research is the design of model DNA substrates, which includes both the photophys. properties of the fluorescent groups and their location relative to a specific recognition site, namely, in the same chain on the 5′-, 3′-side or in the complementary chain opposite the specific site. In this work, we report a comparative study of the sensitivity of various fluorescent DNA base analogs, such as 2-aminopurine (aPu), pyrrolocytosine (CPy), 1,3-diaza-2-oxophenoxazine (tCO) and 3-hydroxychromone (3HC), to conformational transformations of DNA in the process of interaction with formamidopyrimidine-DNA glycosylase (Fpg) from Escherichia coli.
Russian Journal of Bioorganic Chemistry published new progress about DNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, SDS of cas: 452-06-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem