Kunz, Peter C.; Wetzel, Corinna; Bongartz, Melanie; Noffke, Anna Louisa; Spingler, Bernhard published the artcile< Novel multitopic diphos-type ligands>, Computed Properties of 1003-21-0, the main research area is chlorophosphinoethane substitution reaction imidazole thiazole derivative; imidazolyl thiazolyl diphoshine ligand rhodium complex preparation crystal structure; mol structure imidazole thiazole derivative diphosphine ligand rhodium complex; hydrophilicity partition coefficient imidazolyl thiazolyl diphoshine ligand.
Seven novel imidazole and thiazole derivatives of diphos-type ligands are prepared They are of the general structure R2P(CH2)2PR2, where R is imidazol-2-yl (1), 1-methylimidazol-2-yl (2), 1-methylbenzimidazol-2-yl (3), 1-methylimidazol-5-yl (4), 2-isopropylimidazol-4(5)-yl (5), thiazol-2-yl (6), benzothiazol-2-yl (7), thiazol-4-yl (8) or thiazol-5-yl (9). Syntheses involved direct metalation or halogen-metal exchange reactions. E.g., nBuLi reacted with 1-methylbenzimidazole in toluene at -78° and bis(dichlorophosphino)ethane was added and stirred overnight to give 80% yield of bis(di-1-methylbenzimidazol-2-ylphosphino)ethane. Their solubility, especially in aqueous solution, is strongly dependent on the nature of the substituents as is their partition coefficient log D. The crystal structures of compounds 2, 3, 7 and 9 as well as the structure of the Rh complex [(2)2Rh2Cl2]Cl2 (10) were determined
Journal of Organometallic Chemistry published new progress about Coordinative substitution reaction. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Computed Properties of 1003-21-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem