Deng, Libin; Jiang, Wang; Wang, Xiaoning; Merz, Andreas; Hiet, Marie-Sophie; Chen, Yujie; Pan, Xiaoyu; Jiu, Yaming; Yang, Yu; Yu, Bowen; He, Yongning; Tu, Zhengkun; Niu, Junqi; Bartenschlager, Ralf; Long, Gang published the artcile< Syntenin regulates hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes>, SDS of cas: 6823-69-4, the main research area is hepatitis C virus neutralizing antibody syntenin exosome; Exosomes; HCV; Lipo-viro-particles; Neutralizing antibodies; Syntenin; Virions.
Assembly of infectious hepatitis C virus (HCV) particles is known to involve host lipoproteins, giving rise to unique lipo-viro-particles (LVPs), but proteome studies now suggest that addnl. cellular proteins are associated with HCV virions or other particles containing the viral envelope glycoprotein E2. Many of these host cell proteins are common markers of exosomes, most notably the intracellular adaptor protein syntenin, which is required for exosome biogenesis. Furthermore, infectivity of HCV released from syntenin-expressing hepatoma cells and PHHs was more resistant to neutralization by E2-specific antibodies and chronic-phase patient serum. We also found that high E2/syntenin levels in sera correlate with lower serum neutralization capability.E2- and syntenin-containing exosomes are a major type of particle released from cells expressing high levels of syntenin. Efficient production of E2-coated exosomes renders HCV infectivity less susceptible to antibody neutralization in hepatoma cells and PHHs.This study identifies a key role for syntenin in the regulation of E2 secretion via exosomes. Efficient production of E2-coated exosomes was shown to make hepatitis C virus less sensitive to antibody neutralization. These results may have implications for the development of an hepatitis C virus vaccine.
Journal of Hepatology published new progress about Exosome (exocytotic granule). 6823-69-4 belongs to class imidazoles-derivatives, and the molecular formula is C30H30Cl2N6O2, SDS of cas: 6823-69-4.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem