Begtrup, Mikael; Larsen, Peter published the artcile< Alkylation, acylation, and silyation of azoles>, Formula: C4H5BrN2, the main research area is azole alkylation solvent effect; acylation azole anion; silylation azole anion; methylation benzylation azole anion.
Performing alkylation, acylation, and silylation reactions in sep. deprotonation and nucleophilic displacement steps allows for better control of reaction conditions and facilitates problem handling in these processes. In the alkylation of azoles, the alkylating agents and solvents possess individual reaction capabilities which seem to be approx. additive. Monoalkylation occurs if the sum of the normalized reaction potentials is equal or larger than the pKa value of the azole. Dialkylation is avoided by keeping the sum of the normalized reaction potentials below the pKa value of the alkylazole. The applicability of these principles is demonstrated by the development of effective procedures for the methylation, benzylation, acetylation, methoxycarbonylation, and trimethylsilylation of azoles.
Acta Chemica Scandinavica published new progress about Acylation. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Formula: C4H5BrN2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem