Barbay, J. Kent; Cummings, Maxwell D.; Abad, Marta; Castro, Glenda; Kreutter, Kevin D.; Kummer, David A.; Maharoof, Umar; Milligan, Cynthia; Nishimura, Rachel; Pierce, Joan; Schalk-Hihi, Celine; Spurlino, John; Tanis, Virginia M.; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Woods, Craig; Wolin, Ronald; Xue, Xiaohua; Edwards, James P.; Fourie, Anne M.; Leonard, Kristi published the artcile< 6-Substituted quinolines as RORγt inverse agonists>, HPLC of Formula: 1003-21-0, the main research area is quinoline preparation RORt inverse agonist structure activity relationship; IL-17; RORγt; Retinoic acid-related orphan nuclear receptor gamma t; Th17.
We identified 6-substituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). The synthesis of this class of RORγt modulators is reported, and optimization of the substituents at the quinoline 6-position that produced compounds with high affinity for the receptor is detailed. This effort identified mols. that act as potent, full inverse agonists in a RORγt-driven cell-based reporter assay. The X-ray crystal structures of two full inverse agonists, I and II, from this chem. series bound to the RORγt ligand binding domain are disclosed, and we highlight the interaction of a hydrogen-bond acceptor on the 6-position substituent of the inverse agonist with Glu379:NH as a conserved binding contact.
Bioorganic & Medicinal Chemistry Letters published new progress about Hydrogen bond. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, HPLC of Formula: 1003-21-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem