Month: September 2022

Kumar, Amit;Kumar, Ashish;Gupta, Rakesh Kumar;Paitandi, Rajendra Prasad;Singh, Krishna Beer;Trigun, Surendra Kumar;Hundal, Maninder Singh;Pandey, Daya Shankar published 《Cationic Ru(II), Rh(III) and Ir(III) complexes containing cyclic π-perimeter and 2-aminophenyl benzimidazole ligands: Synthesis, molecular structure, DNA and protein binding, cytotoxicity and anticancer activity》. The research results were published in《Journal of Organometallic Chemistry》 in 2016.Product Details of 5805-39-0 The article conveys some information:

Synthesis, characterization, DNA and protein binding as well as anticancer activity of the organometallic complexes [(η⁶-C₆H₆)RuCl(APBI)]Cl (1), [(η⁶-p-MeC₆H₄Prⁱ)RuCl(APBI)]Cl (2), [(η⁶-C₆Me₆)RuCl(APBI)]Cl (3), [(η⁵-C₅Me₅)RhCl(APBI)]Cl·H₂O (4) and [(η⁵-C₅Me₅)IrCl(APBI)]Cl·H₂O (5) containing 2-aminophenyl benzimidazole (APBI) have been described. The complexes 1–5 exhibited strong DNA, protein binding and anticancer activity against cervical cancer (SiHa) cell line. Their binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) have been examined by absorption and emission spectral studies. Strong interactions between complexes and CT-DNA have been affirmed by absorption spectral and EthBr displacement studies, while interaction with BSA via static quenching explored by fluorescence titration, synchronous and 3D fluorescence spectroscopy. The interactions between 1–5 and DNA has also been scrutinized by ¹H NMR spectral studies using guanosine as a model for DNA. These results have been supported by DFT calculations and mol. docking studies. Cytotoxicity, apoptosis and in vitro anticancer activity of 1–5 toward SiHa cell line have been investigated by MTT assay and acridine (AO)/ethidium bromide (EthBr) fluorescence staining. Overall results revealed that DNA and protein binding, as well as anticancer activity of 1–5 follows the order as 5 > 3 > 2 > 1 > 4. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Product Details of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formula: C13H11N3In 2018, Matysiak, Joanna;Skrzypek, Alicja;Glaszcz, Urszula;Matwijczuk, Arkadiusz;Senczyna, Bogdan;Wietrzyk, Joanna;Krajewska-Kulak, Elzbieta;Niewiadomy, Andrzej published 《Synthesis and biological activity of novel benzoazoles, benzoazines and other analogs functionalized by 2,4-dihydroxyphenyl moiety》. 《Research on Chemical Intermediates》published the findings. The article contains the following contents:

Novel benzoazoles, benzoazines, benzothiazoles, benzothiazines and other related compounds possessing a 2,4-dihydroxyphenyl moiety were prepared The compounds were obtained by the reaction of sulfinylbis[(2,4-dihydroxyphenyl)methanethione]s with the appropriate heterocyclic amines or hydrazines. Human cancer lines, Candida species and phytopathogenic fungi were used for the evaluation of biol. potency of compounds Addnl., drug-like properties were estimated in silico. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Today I want to share an article with you. The article is 《An efficient and stable magnetic nano-biocatalyst for biodiesel synthesis in recyclable ionic liquids》,you can find this article in 《Biomass Conversion and Biorefinery》. The following contents are mentioned:

Abstract: The process of jatropha oil transesterification was studied for biodiesel production Rhizomucor miehei lipase (RML) immobilized on 3-aminopropyltriethoxysilane functionalized magnetic Fe₃O₄ was employed as a biocatalyst. The immobilized lipase was confirmed by scanning electron microcopy (SEM), Fourier transform IR spectra (FT-IR), thermogravimetric anal. (TGA), vibrating sample magnetometer (VSM), and confocal laser scanning microscopy (CLSM) techniques. The efficient biodiesel synthesis in ionic liquids using immobilized RML was demonstrated. Fifteen kinds of ionic liquids based on different alkyl chain lengths of the Me imidazolium cation ([C₂MIM], [C₄MIM], [C₈MIM], [C₁₂MIM], and [C₁₆MIM]) combined with [NTf₂], [N(CN)₂], [PF₆] or [BF₄] anions were assayed as reaction media for RML producing biodiesel. The highest synthetic activity of immobilized RML appeared in [BMIM][PF₆], which is more than five times higher than the free enzyme. The enzyme catalytic activity remained 60even after the magnetic nano-biocatalyst and ionic liquid had been reused 5 times in a 48-h reaction cycle. In addition, the immobilized enzyme exhibited excellent storage stability with almost no decrease in catalytic activity after storing at -20 °C for 98 days.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Seyednejhad, Sajedeh;Khalilzadeh, Mohammad A.;Zareyee, Daryoush;Sadeghifar, Hasan;Venditti, Richard published 《Cellulose nanocrystal supported palladium as a novel recyclable catalyst for Ullmann coupling reactions》. The research results were published in《Cellulose (Dordrecht, Netherlands)》 in 2019.Application of 5805-39-0 The article conveys some information:

A new Pd catalyst chem. bonded to cellulose nanocrystals surfaces was developed. 2-(1H-benzo[d]imidazol-2-yl)aniline (BIA), tosylated cellulose nanocrystals (CNC-TOS) and PdCl₂ were the reactants for the synthesis of the new catalyst designed to be used for the Ullmann reaction. The modified cellulose nano catalyst was characterized with various anal. tools. The catalyst had excellent selectivity and activity in a short reaction time (45 min) and outstanding TON (490) and TOF (1960) values. The nano catalyst was determined to be reusable for at least eight cycles. The Pd catalyst chem. bonded to cellulose nanocrystals surface indicated excellent catalytic efficiency for the Ullmann C-O reaction when it was compared to com. palladium catalysts.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Leal, Jorge;Santos, Lucia;Fernandez-Aroca, Diego M.;Cuevas, J. Vicente;Martinez, M. Angeles;Massaguer, Anna;Jalon, Felix A.;Ruiz-Hidalgo, M. Jose;Sanchez-Prieto, Ricardo;Rodriguez, Ana M.;Castaneda, Gregorio;Dura, Gema;Carrion, M. Carmen;Barrabes, Silvia;Manzano, Blanca R. published 《Effect of the aniline fragment in Pt(II) and Pt(IV) complexes as anti-proliferative agents. Standard reduction potential as a more reliable parameter for Pt(IV) compounds than peak reduction potential》. The research results were published in《Journal of Inorganic Biochemistry》 in 2021.Electric Literature of C13H11N3 The article conveys some information:

The problems of resistance and side effects associated with cisplatin and other chemotherapeutic drugs have boosted research aimed at finding new compounds with improved properties. The use of platinum(IV) prodrugs is one alternative, although there is some controversy regarding the predictive ability of the peak reduction potentials. In the work described here a series of fourteen chloride Pt(II) and Pt(IV) compounds was synthesized and fully characterized. The compounds contain different bidentate arylazole heterocyclic ligands. Their cytotoxic properties against human lung carcinoma (A549), human breast carcinoma (MCF7) and human colon carcinoma (HCT116 and HT29) cell lines were studied. A clear relationship between the type of ligand and the anti-proliferative properties was found, with the best results obtained for the Pt(II) compound that contains an aniline fragment, (13), thus evidencing a pos. effect of the NH₂ group. Stability and aquation studies in DMSO, DMF and DMSO/water mixtures were carried out on the active complexes and an in-depth anal. of the two aquation processes, including DFT anal., of 13 was undertaken. It was verified that DNA was the target and that cell death occurred by apoptosis in the case of 13. Furthermore, the cytotoxic derivatives did not exhibit haemolytic activity. The reduction of the Pt(IV) compounds whose Pt(II) congeners were active was studied by several techniques. It was concluded that the peak reduction potential was not useful to predict the ability for reduction However, a correlation between the cytotoxic activity and the standard reduction potential was found.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Electric Literature of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hasan, Hiba Ali;Abdulmalek, Emilia;Abdul Rahman, Mohd Basyaruddin;Shaari, Khozirah Binti;Yamin, Bohari Mohd.;Chan, Kim Wei published 《Microwave synthesis, crystal structure, antioxidant, and antimicrobial study of new 6-heptyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c] quinazoline compound》 in 2018. The article was appeared in 《Chemistry Central Journal》. They have made some progress in their research.Synthetic Route of C13H11N3 The article mentions the following:

A comparative study between two methods, (microwave-assisted and conventional heating approaches), was performed to synthesize a new quinazoline derivative from 2-(2-aminophenyl)-1H-benzimidazole and octanal to produce 6-heptyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline (OCT). The compound was characterised using FTIR, ¹H and ¹³C NMR, DIMS, as well as X-ray crystallog. The most significant peak in the ¹³C NMR spectrum is C-7 at 65.5 ppm which confirmed the cyclization process. Crystal structure anal. revealed that the mol. growed in the monoclinic crystal system P2₁/n space group and stabilized by an intermol. hydrogen bond between the N1-H1A···N3 atoms. The crystal packing anal. showed that the mol. adopts zig-zag one dimensional chains. Fluorescence study of OCT revealed that it produced blue light when expose to UV-light and its quantum yield equal to 26%. Antioxidant activity, which included DPPH· and ABTS^·+ assays was also performed and statistical anal. was achieved via a paired T-test using Minitab 16 software with P < 0.05. Also, the antimicrobial assay against two Gram-pos., two Gram-neg., and one fungus was screened for these derivatives Using microwave to synthesize OCT have drastically reduced reaction time, and increased yield. OCT showed good antioxidant activity in one of the tests and moderate antimicrobial activity. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Synthetic Route of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

HPLC of Formula: 5805-39-0In 2019, Hu, Wangqin;Yang, Wen;Gong, Tingfeng;Zhou, Weiqun;Zhang, Yuhan published 《Multi-stimuli responsive properties switch by intra- and inter-molecular charge transfer constructed from triphenylamine derivative》. 《CrystEngComm》published the findings. The article contains the following contents:

Combining triphenylamine (TPA) and 2-(1H-benzo[d]imidazol-2-yl) aniline (BI), a typical fluorescent dye, TPA-BI, was designed and synthesized. The photo-phys. properties of this compound were investigated both in solution and the solid state. TPA-BI showed a strong AIEE effect and its relative fluorescence quantum yield (φ_f) was up to 63.4% in the aggregation state. The tunable fluorescence phenomenon by the MCF effect was observed between the amorphous (bluish violet) and crystalline (green) states, and the absolute φ_f was determined to be 56.2% and 21.9%, resp., by the integral sphere method. Meanwhile, pH titration experiments exhibited the tunable fluorescence phenomenon in different pH solutions Thus, TPA-BI could also be used as a fluorescent switch from green to bluish-violet based on its response to volatile acidic and alk. organic compounds in the solid state repeatedly without fatigue and destruction under UV illumination (365 nm), which can be explained by the reversible transformation by protonation and deprotonation. The protonation process was further confirmed in detail by ¹HNMR titration experiments D. functional theory (DFT) and time-dependent d. functional theory (TD-DFT) were used to predict the multi-stimuli responsive fluorescence properties. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 HPLC of Formula: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nakhaei-Kohani, Reza;Ali Madani, Seyed;Mousavi, Seyed-Pezhman;Atashrouz, Saeid;Abedi, Ali;Hemmati-Sarapardeh, Abdolhossein;Mohaddespour, Ahmad published 《Machine learning assisted Structure-based models for predicting electrical conductivity of ionic liquids》 in 2022. The article was appeared in 《Journal of Molecular Liquids》. They have made some progress in their research.Recommanded Product: 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride The article mentions the following:

Ionic liquids (ILs) have attracted a great deal of attention as vital compounds that are widely used in various industries, such as the chem. and petroleum industries. Therefore, determining the properties of ionic liquids, such as elec. conductivity (EC), is an important issue. In this study, four different machine learning approaches including K-nearest neighbors (KNN), extreme gradient boosting (XGB), adaptive boosting-decision tree (Ada-DT), and adaptive boosting-support vector regression (Ada-SVR) were established to predict EC of ILs based on two categories namely: (I) smart models based on ILs chem. structure and temperature, and (II) smart models based on ILs thermodn. properties and temperature For this purpose, 2625 laboratory data points corresponding to 225 ILs have been used. The results showed that based on Model (I), KNN model with root mean square error (RMSE) and coefficient of determination (R2) values of 0.1976 and 0.9935, resp., is the best model in predicting EC. Also, based on Model (II), the XGB model with RMSE and R2 values of 0.1447 and 0.9965, resp., is the most powerful and accurate model for estimating elec. conductivity Sensitivity anal. revealed that temperature and mol. weight have a direct and inverse effect on increasing the elec. conductivity of ILs, resp. The investigation of the effects of different chem. bonds (in the chem. structure of ionic liquids) on ILs EC showed that -CH2- and > N- substructures have the most neg. and pos. effect on EC, resp. Also, the proposed smart paradigms were capable of accurately predicting the effect cation alkyl chain length on elec. conductivity Based on the leverage technique assessment more than 95% of total data points are in a valid region which indicates that intelligent models are reliable. Consequently, the introduction of intelligent models based on the chem. structure of ILs, the much broader data bank, and the higher accuracy of the proposed models are among the innovations and advantages of this study compared to the previous researches. Findings of this study highlights that chem. structure-intelligence based approaches provide robust, reliable and accurate way to predict EC of ILs. To complete the study, the researchers used 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Recommanded Product: 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chang, Ken-Lin;Muega, Sherwin C.;Ofrasio, Bjorn Ivan G.;Chen, Wei-Hsin;Barte, Emely G.;Abarca, Ralf Ruffel M.;de Luna, Mark Daniel G. published 《Synthesis of 5-hydroxymethylfurfural from glucose, fructose, cellulose and agricultural wastes over sulfur-doped peanut shell catalysts in ionic liquid》 in 2022. The article was appeared in 《Chemosphere》. They have made some progress in their research.SDS of cas: 65039-09-0 The article mentions the following:

In this study, waste peanut shells were sulfur-impregnated and used as acid catalysts in the presence of an ionic liquid for the conversion of fructose, glucose, and cellulose into 5-hydroxymethylfurfural, a useful chem. intermediate for biofuel production Effects of sulfur-doping duration (1 h and 5 h), solvent type and proportion, reaction temperature (130°C, 140°C, and 150°C), time (30-240 min), catalyst-to-substrate ratio (1-2.5 m/m), and agricultural residue (peanut shell, Canada wheat straw, water hyacinth, stalk, and reed) on HMF yields were investigated. Monophasic and biphasic ionic liquids such as [amim]Cl, [bmim]HSO₄, and [emim]Cl were employed in combination with choline chloride and DMSO to improve HMF yields. Results show that peanut shells subjected to prolonged sulfur impregnation produced higher HMF yields. At 130°C and 2 h, HMF yields from fructose and glucose reached 94.6% and 55.1%, resp. Higher reaction temperatures improved HMF yields and accelerated conversion rates for the sugar substrates. Moreover, HMF production from waste biomass namely, peanut shells, peanut stalk, Canadian wheat straw, reed, and water hyacinth were examined in sep. one-pot catalytic reactions. Overall, the study showed the effectiveness of sulfur-doped peanut shells as solid acid catalysts for the synthesis of HMF from various sources and the results may be used in designing large-scale production of furanic biofuel precursors from agricultural wastes. The experimental procedure involved many compounds, such as 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.SDS of cas: 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rajh, Ava;Arcon, Iztok;Bucar, Klemen;Zitnik, Matjaz;Petric, Marko;Vizintin, Alen;Bitenc, Jan;Kosir, Urban;Dominko, Robert;Gretarsson, Hlynur;Sundermann, Martin;Kavcic, Matjaz published 《Characterization of electrochemical processes in metal-organic batteries by x-ray Raman spectroscopy》 in 2022. The article was appeared in 《Journal of Physical Chemistry C》. They have made some progress in their research.Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride The article mentions the following:

X-ray Raman spectroscopy (XRS) is an emerging spectroscopic technique that utilizes inelastic scattering of hard X-rays to study X-ray absorption edges of low Z elements in bulk material. It was used to identify and quantify the amount of carbonyl bonds in a cathode sample, in order to track the redox reaction inside metal-organic batteries during the charge/discharge cycle. XRS was used to record the oxygen K-edge absorption spectra of organic polymer cathodes from different multivalent metal-organic batteries. The amount of carbonyl bond in each sample was determined by modeling the oxygen K-edge XRS spectra with the linear combination of two reference compounds that mimicked the fully charged and the fully discharged phases of the battery. To interpret exptl. XRS spectra, theor. calculations of oxygen K-edge absorption spectra based on d. functional theory were performed. Overall, a good agreement between the amount of carbonyl bond present during different stages of battery cycle, calculated from linear combination of standards, and the amount obtained from electrochem. characterization based on measured capacity was achieved. The electrochem. mechanism in all studied batteries was confirmed to be a reduction of double carbonyl bond and the intermediate anion was identified with the help of theor. calculations X-ray Raman spectroscopy of the oxygen K-edge was shown to be a viable characterization technique for accurate tracking of the redox reaction inside metal-organic batteries. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem