Month: September 2022

Reference of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride《Deep eutectic solvents coupled with (NH₄)₃H₆CoMo₆O₂₄ trigger aerobic oxidation of 5-hydroxymethylfurfural to 5-formyl-2-furancarboxylic acid》 was published in 2022. The authors were Sun, Yanbin;Yang, Kaixuan;Zhu, Zhiguo;Su, Ting;Ren, Wanzhong;Lu, Hongying, and the article was included in《Chemical Communications (Cambridge, United Kingdom)》. The author mentioned the following in the article:

An Anderson-type polyoxometalate (NH4)3H6CoMo6O24 in deep eutectic solvents exhibited outstanding catalytic performance for the selective aerobic oxidation of HMF to FFCA. It is potentially a promising and highly environmentally friendly approach for biomass conversion. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Reference of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride《Synthesis of adamantane by ionic liquid-promoted isomerization of tricyclo[5.2.1.0^2,6]decane and H₂SO₄-mediated hydroisomerization of pentacyclo[4.4.0.0^2,4.0^3,7.0^8,10]decane》 was published in 2022. The authors were Aminov, R. I.;Ramazanov, I. R.;Khusnutdinov, R. I., and the article was included in《Russian Chemical Bulletin》. The author mentioned the following in the article:

Adamantane was synthesized by skeletal isomerization of endo- and exo-tricyclo[5.2.1.0^2,6]^–decanes in the presence of ionic liquid [Et₃NH]⁺[Al₂Cl₇]^–-CuSO₄. A new method to synthesize adamantane in 75% yield by H₂SO₄-mediated hydroisomerization of its new precursor, pentacyclo[4.4.0.0^2,4.0^3,7.0^8,10]decane, was developed. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Joshi, P. P.;Dodkey, A. M. published 《Synthesis and characterization of new substituted 2-(2-aryl-diazenyl)-H-benzo(d)-imidazole derivatives》. The research results were published in《World Journal of Pharmaceutical Research》 in 2017.Related Products of 5805-39-0 The article conveys some information:

A series of new substituted 2-(2-aryl-diazenyl)benzo(d)imidazoles I [R = H, Cl, CH₃; R¹ = H, Cl, NO₂; Ar = 2-HOC₆H₄, 2-hydroxy-1-naphthyl] was synthesized via coupling reaction of substituted 2-[(1H)-benzo(d)imidazol-2-yl]anilines with 2-naphthol and phenol. The structures of the products were confirmed from ¹H-NMR, ¹³C-NMR and IR spectra. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Related Products of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computed Properties of C13H11N3《Synthesis, characterization and biological evaluation of benzimidazole derivatives》 was published in 2018. The authors were Anand, Keshav;Wakode, Sharad, and the article was included in《International Journal of Pharmaceutical Sciences and Research》. The author mentioned the following in the article:

A series of benzimidazole derivatives were synthesized by a single step process by reacting o-phenylenediamine and benzoic acid. The purity and structure confirmation of the synthesized compounds were done by TLC and ¹H-NMR. The compounds were evaluated for anti-microbial, anti-fungal and antioxidant activity. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Computed Properties of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kaur, Narinder;Singh, Jasminder;Raj, Pushap;Singh, Narinder;Singh, Harpreet;Sharma, Sanjeev K.;Kim, Deuk Young;Kaur, Navneet published 《ZnO decorated with organic nanoparticles based sensor for the ratiometric selective determination of mercury ions》 in 2016. The article was appeared in 《New Journal of Chemistry》. They have made some progress in their research.Computed Properties of C13H11N3 The article mentions the following:

ZnO nanoparticles decorated with organic receptor, 2-[[[2-(1H-benzimidazol-2-yl)phenyl]imino]methyl]phenol, were prepared and the resultant compound (N1) was studied for its metal recognition ability. N1 is selective for mercury ions (Hg²⁺) in a DMSO/water mixture in a ratio of 7 : 3 and possessed no interference from any of the potential interferent metal ions. The crystal size and morphol. of ZnO was characterized using various spectroscopic and diffraction techniques like SEM, XRD, dynamic light scattering (DLS), etc. Surface decoration of the ZnO with receptor 1 is confirmed using NMR spectroscopy. On successive additions of Hg²⁺ ions, the fluoroscence intensity of the compound was quenched at 427 nm with enhancement of the peak at 482 nm, which led to ratiometric sensor development for the recognition of mercury ions having a detection limit of 0.19 nM. The prepared receptor was also tested for real sample application by preparing a known concentration of Hg²⁺ solution and it was found to respond well with an accuracy >90%. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Computed Properties of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Today I want to share an article with you. The article is 《DMSO as C1 Source under Metal- and Oxidant-free Conditions: NH₄SCN-mediated Synthesis of Quinazolinone and Dihydroquinazolin-4(1H)-one Derivatives》,you can find this article in 《Asian Journal of Organic Chemistry》. The following contents are mentioned:

A new and efficient strategy for the development of quinazolinones I(R = iso-Pr, cyclohexyl, 4-methylphenyl, thiophen-2-ylmethyl, etc.) and dihydroquinazolin-4(1H)-ones II (R¹ = Me, Ph, Bn, etc.; R² = H, Bu, 4-chlorophenyl, pyridin-4-yl, etc.) promoted by ammonium thiocyanate is reported. Most remarkably, DMSO is used for solvent as well as methine and bridged methylene source to obtain a wide variety of new N,N-disubstituted 2,3-dihydroquinazolin-4(1H)-ones II. This transformation possesses significant advantages such as metal- and oxidant-free, non-acidic medium, simple condition, good functional group tolerance and broad substrate scope. Besides, this process could be readily scaled up and applied to drug mols. synthesis. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rocha, Ines L. D.;da Costa Lopes, Andre M.;Ventura, Sonia P. M.;Coutinho, Joao A. P. published 《Selective Separation of Vanillic Acid from Other Lignin-Derived Monomers Using Centrifugal Partition Chromatography: The Effect of pH》. The research results were published in《ACS Sustainable Chemistry & Engineering》 in 2022.Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride The article conveys some information:

In this work, centrifugal partition chromatog. (CPC) assisted by a polyethylene glycol (PEG)/sodium polyacrylate (NaPA) aqueous biphasic system (ABS) was applied in the separation of five lignin-derived monomers (vanillin, vanillic acid, syringaldehyde, acetovanillone, and p-hydroxybenzaldehyde). The influence of the system pH (unbuffered, pH 5, and pH 12) and added electrolytes (inorganic salts or ionic liquids (ILs)) on the compound partition was initially evaluated. The obtained data revealed that ILs induced more adequate partition coefficients (K < 5) than inorganic salts (K > 5) to enable separation performance in CPC, while alk. conditions (pH 12) demonstrated a pos. impact on the partition of vanillic acid. CPC runs, with buffered ABS at pH 12, enabled a selective separation of vanillic acid from other lignin monomers. Under these conditions, a distinct interaction between the top (PEG-rich) and bottom (NaPA-rich) phases of the ABS with the double deprotonated form of vanillic acid is expected when compared to the remaining lignin monomers (single deprotonated). This is an impactful result that shows the pH to be a crucial factor in the separation of lignin monomer compounds by CPC, while only unbuffered systems have been previously studied in the literature. Finally, the recovery of vanillic acid up to 96% purity and further recycling of ABS phase-forming components were approached as a proof of concept through the combination of ultrafiltration and solid-phase extraction steps.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Liu, Qian;Zhang, Xianglan published 《Highly efficient separation of phenolic compounds from low-temperature coal tar by composite extractants with low viscosity》. The research results were published in《Journal of Molecular Liquids》 in 2022.Category: imidazoles-derivatives The article conveys some information:

Highly efficient separation of phenolic compounds from low-temperature coal tar (LTCT) is significant in the industry. In this work, composite extractants composed of imidazolium-based ionic liquids (ILs) and solvents were used to sep. phenolic compounds from model oil and LTCT. First, the COSMO-RS model was used to screen composite extractants that combined the infinite dilution thermodn. indexes and liquid-liquid equilibrium (LLE) calculations Meanwhile, the separation mechanism was analyzed by σ-profile and σ-potential. Then, the reliability of the COSMO-RS model was validated by LLE experiments and FT-IR. The viscosity of composite extractants with high separation performance was further determined Among the composite extractants, 1-ethyl-3-methyl-imidazolium hydrogen sulfate ([emim][HSO4])/ethylene glycol (EG) was selected as the most suitable extractant in the separation process. The m-cresol extraction efficiency and cumene entrainment were 98.1% and 8.3%, resp., at a [emim][HSO₄]:EG molar ratio of 1:2, a temperature of 25 °C, and a composite extractant: model oil mass ratio of 1:1. Moreover, the viscosity of [emim][HSO₄]:EG (1:2) was only 51.8 cP at 25 °C and decreased by 95.6% compared with pure [emim][HSO₄], which enhanced the mass transfer in the separation process. The [emim][HSO₄]:EG (1:2) could be regenerated and reused without significant reduction in separation performance. Finally, [emim][HSO₄]:EG (1:2) was applied to sep. phenolic compounds from LTCT with a phenol extraction efficiency of more than 99.9% and a neutral oil entrainment of 8.3%, providing a promising prospect for the separation of phenolic compounds1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Category: imidazoles-derivatives

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Korrapati, Suresh Babu;Yedla, Poornachandra;Pillai, Girinath G.;Mohammad, Faruq;Ch., Venkata Ramana Reddy;Bhamidipati, Pranav;Amanchy, Ramars;Syed, Riyaz;Kamal, Ahmed published 《In-silico driven design and development of spirobenzimidazo-quinazolines as potential DNA gyrase inhibitors》. The research results were published in《Biomedicine & Pharmacotherapy》 in 2021.Quality Control of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article conveys some information:

DNA gyrase and Topoisomerase IV are promising antibacterial drug targets as they regulate bacterial DNA replication and topol. In a quest for novel DNA topoisomerase inhibitors, a multidisciplinary approach was adopted that involves computational prediction of binding sites and mol. modeling followed by green synthesis and biol. evaluation of antibacterial activity of spirobenzimidazo quinazolines derivatives Using basic quantum chem. principles, we evaluated spirobenzimidazo quinazolines derivatives with their pharmacokinetic profiles. Based on the results of the aforesaid in-silico studies, we synthesized a series of titled compounds using green synthetic methodol. that were validated as potential antimicrobial agents. Quantum chemoinformatics based predicted activity for the synthesized compounds 9b, 9c, and 9j was concomitant with biol. evaluation of broadspectrum antibacterial activity. Biol. evaluation revealed that inhibition of biofilm formation was due to their potential antibacterial activity. We believe that the novel spirobenzimidazo quinazolines have the potential to be alternatives to aminocoumarins and classical quinazolines upon detailed target specific biol. studies. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Quality Control of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Shree, Ganesan Jeya;Sivaraman, Gandhi;Siva, Ayyanar;Chellappa, Duraisamy published 《Anthracene- and pyrene-bearing imidazoles as turn-on fluorescent chemosensor for aluminum ion in living cells》 in 2019. The article was appeared in 《Dyes and Pigments》. They have made some progress in their research.Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

A newly designed 2-(2-Aminophenyl)-1H-benzimidazole integrated anthracene/pyrene derivatives as efficient chemosensors were synthesized. The probes N-(anthracen-9-ylmethylene)-2-(1H-benzo[d]imidazol-2-yl)aniline (ANP) and N-(pyren-1-ylmethylene)-2-(1H-benzo[d]imidazol-2-yl)-aniline (PYP) exhibited high selectivity and sensitivity towards Al³⁺ ion over other interfering and competing cations in aqueous solution Job’s plot anal. reveals that the interaction of ANP/PYP with Al³⁺ was 1:1 binding stoichiometry. The detection limit of probes ANP and PYP for Al³⁺ ions are 1.85 × 10^-7 M and 1.08 × 10^-7 M, resp. The DFT/TD-DFT calculations have also been revealed that the ICT mechanism is responsible for the observed photophys. changes. Moreover, the probes ANP and PYP were applicable to image intracellular Al³⁺ ions in living cells via confocal fluorescence microscopy technique. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem