Month: September 2022

Baxter, Eric T.;Zhang, Jun;Tan, Shuai;Nguyen, Manh-Thuong;Zhang, Difan;Yuan, Qinqin;Cao, Wenjin;Wang, Xue-Bin;Prabhakaran, Venkateshkumar;Glezakou, Vassiliki-Alexandra;Johnson, Grant E. published 《Functionalization of Electrodes with Tunable [EMIM]_x[Cl]_x+1^– Ionic Liquid Clusters for Electrochemical Separations》 in 2022. The article was appeared in 《Chemistry of Materials》. They have made some progress in their research.Synthetic Route of C6H11ClN2 The article mentions the following:

Functionalization of electrodes with clusters of hydrophobic mols. may improve the energy efficiency and selectivity of electrochem. separations by modulating the desolvation process occurring at the interface. Ionic liquids (ILs), which have a broad range of compositions and properties, are potential candidates for controlling the transport, desolvation, and adsorption of target ions at electrochem. interfaces. Herein, the authors report a joint exptl. and theor. study of the structure, stability, and selective adsorption properties of IL clusters 1-ethyl-3-methylimidazolium chloride [EMIM]_x[Cl]_x+1^– (x = 1-10) and demonstrate their ability to adsorb and sep. ions from the solution The structure and stability of the IL clusters are determined exptl. using high-mass-resolution electrospray ionization mass spectrometry, collision-induced dissociation, and neg.-ion photoelectron spectroscopy. The global optimization theory and ab initio mol. dynamics simulations provide mol.-level insights into the bonding and structural fluxionality of these species. Ion soft landing was used to selectively functionalize the surface of highly oriented pyrolytic graphite (HOPG) working electrodes with [EMIM]₁[Cl]₂^–, [EMIM]₃[Cl]₄^–, and [EMIM]₅[Cl]₆^– clusters. Kelvin probe microscopy provides insights into the relative stability of the clusters on HOPG and their effect on the work function of IL-functionalized electrodes. Cyclic voltammetry measurements reveal the irreversible adsorption of Fe(CN)₆^4-/3- anions during redox cycling, while electrochem. impedance spectroscopy indicates a substantial decrease in the electron transfer resistance of the IL-functionalized electrodes due to adsorption of Fe(CN)₆^4-/3-. Overall, the authors’ findings demonstrate that IL clusters with different sizes and stoichiometry may be used to increase the efficiency of electrochem. separations, opening new horizons in selective electrode functionalization. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Synthetic Route of C6H11ClN2

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride《Ethyl-, vinyl- and ethynylcyanoborates: room temperature borate ionic liquids with saturated and unsaturated hydrocarbon chains》 was published in 2022. The authors were Schopper, Nils;Zapf, Ludwig;Sprenger, Jan A. P.;Ignat’ev, Nikolai V.;Finze, Maik, and the article was included in《Chemical Communications (Cambridge, United Kingdom)》. The author mentioned the following in the article:

Ethyl-, vinyl- and ethynyltricyano and dicyanofluoroborates were prepared on a gram scale(coating) from com. available potassium trifluoroborates and trimethylsilyl cyanide. Salt metathesis resulted in the corresponding EMIm-salts that are hydrophobic room-temperature ionic liquids (RTILs). The new RTILs exhibit unprecedented large electrochem. windows in combination with high thermal stabilities, low dynamic viscosities and high specific conductivities. These properties make them promising materials, especially for electrochem. applications.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Reference of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sharada, Duddu S.;Shinde, Anand H.;Patel, Srilaxmi M.;Vidyacharan, Shinde published 《Scaffold Diversity through a Branching Double-Annulation Cascade Strategy: Iminium-Induced One-Pot Synthesis of Diverse Fused Tetrahydroisoquinoline Scaffolds》 in 2016. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Synthetic Route of C13H11N3 The article mentions the following:

A branching double-annulation cascade (BDAC) strategy for diverse and complex fused THIQ scaffolds via a highly reactive iminium-induced one-pot double-cyclization sequence involving Pictet-Spengler-type cyclization has been developed for the first time. The salient features of this protocol are that it allows direct and rapid access to unprecedented diverse fused THIQ skeletons, is metal/catalyst free, has a cleaner reaction profile, provides good to excellent yields, and is a convenient approach. This catalyst-free domino process facilitates the double annulation with a variety of scaffold building agents via two C-N and one C-X (X = C, N, O) bond formation in a single step under uniform reaction conditions. Furthermore, we reveal an unusual dual BDAC sequence leading to N-N-linked isoquinoline dimer. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Synthetic Route of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Si, Wei-Jie;Wang, Xiao-Bin;Chen, Min;Wang, Meng-Qi;Lu, Ai-Min;Yang, Chun-Long published 《Design, synthesis, antifungal activity and 3D-QSAR study of novel pyrazole carboxamide and niacinamide derivatives containing benzimidazole moiety》 in 2019. The article was appeared in 《New Journal of Chemistry》. They have made some progress in their research.Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

A series of novel pyrazole carboxamide I (R¹ = H, Cl, Me; R² = Me, CF₃), II (R¹ = H, Cl, Me; R² = Me, i-Bu) and niacinamide derivatives III (R¹ = H, Cl, Me; R² = H, Cl, SH) containing a benzimidazole moiety were designed and synthesized as antifungal candidate agents. The structure of compound I (R¹ = H; R² = Me) was confirmed by single crystal X-ray diffraction anal. The antifungal activities of the target compounds were evaluated in vitro against four phytopathogenic fungi (namely Botrytis cinerea, Rhizoctonia solani, Fusarium graminearum and Alternaria solani) by the mycelium growth inhibition method. The bioassay results indicated that some of the compounds exhibited good antifungal activity against B. cinerea at 100 μg ML^-1 compared to other three fungi. In order to better explore the structure-activity relationship (SAR), the EC₅₀ values of target compounds against B. cinerea were measured and assessed. Subsequently, a 3D quant. structure-activity relationship (3D-QSAR) study was carried out using the comparative mol. field anal. (CoMFA) technique based on the inhibitory activities of tested compounds against B. cinerea. Mol. modeling results revealed fine predictive ability with cross-validated q² and non-cross-validated r² values of 0.578 and 0.850, resp. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Iniya, Murugan;Vidya, Balasubramanian;Anand, Thangaraj;Sivaraman, Gandhi;Jeyanthi, Dharmaraj;Krishnaveni, Karuppiah;Chellappa, Duraisamy published 《Microwave-Assisted Synthesis of Imidazoquinazoline for Chemosensing of Pb²⁺ and Fe³⁺ and Living Cell Application》. The research results were published in《ChemistrySelect》 in 2018.COA of Formula: C13H11N3 The article conveys some information:

An efficient dual-responsive fluorescent probe based on imidazoquinazoline has been synthesized using microwave-assisted solvent-free condition. Its sensing behavior towards Pb²⁺ and Fe³⁺ has been investigated sep. through fluorescence, absorbance and visual fluorescence color changes in different solvent systems. Interestingly, the binding event triggers selective “turn-on” response to Pb²⁺ and ratiometric response to Fe³⁺ against other commonly coexistent metal ions. The observed exptl. data has been rationalized in terms of theor. calculations The living cell imaging experiment demonstrated the practical value of the sensor in mapping intracellular Fe³⁺ and Pb²⁺ distributions in biol. systems. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 COA of Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Odame, F.;Hosten, Eric C.;Betz, R.;Krause, J.;Frost, Carminita L.;Lobb, K.;Tshentu, Zenixole R. published 《Synthesis, characterization, computational studies and DPPH scavenging activity of some triazatetracyclic derivatives》 in 2021. The article was appeared in 《Journal of the Iranian Chemical Society》. They have made some progress in their research.SDS of cas: 5805-39-0 The article mentions the following:

Some dihydrobenzo[4,5]imidazo[1,2-c]quinazolines I (R = Me, 2-methylpropyl, Ph, etc.; R¹ = H, Me) have been synthesized from aldehydes RCHO and ketones RC(O)CH₃, using the ketones as both reagents and solvents and THF (THF) as the solvent for the aldehydes, to yield the triazatetracyclics I. The compounds I have been characterized with spectroscopy and microanal. The crystal structures of triazatetracyclics I [R = Me, R¹ = Me (II); R = Et, R¹ = Me (III); and R = Ph, R¹ = H (IV)] have been discussed. The computed NMR, IR, mol. electrostatic potential and frontier MOs of compounds II, III and IV have been discussed. The M06 functional gave most of its values closest to the exptl. values for the bond lengths and bond angles of compounds II and III. For compound IV, none of the functionals gave values for bond lengths and bond angles that were consistent with the exptl. values, but M06 gave values closest to exptl. values. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity of the triazatetracyclics showed that compound II exhibits significant DPPH scavenging activity with an IC₅₀ of 56.18μM compared to 2.37μM for ascorbic acid. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 SDS of cas: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fu, Qing-Qing;Hu, Jing-Han;Yao, Ying;Yin, Zhi-Yuan;Gui, Kai;Xu, Nuo;Niu, Li-Yi;Zhang, Yu-Qing published 《A benzimidazole derivative based LMCT sensor for the detection of Cu²⁺ in DMSO/H₂O (2:3 v/v) solution and its application in implication logic gates》. The research results were published in《Journal of Photochemistry and Photobiology, A: Chemistry》 in 2020.Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article conveys some information:

Reversible dual channel sensor F2 for detection Cu²⁺ is designed and synthesized. F2 is substantially unaffected by other cationic ions during the recognition of Cu²⁺. It is worth noting that the low detection limit of sensor F2 is 9.09 × 10^-9, and the detection limit is lower that to the reported sensor for identifying Cu²⁺. Through various experiments and characterization, it is proved that ligand-metal charge transfer (LMCT) is the interaction mechanism between F2 and Cu²⁺. It is further certified that the stoichiometry between F2 and Cu²⁺ is 1:1. In addition, the fluorescence changes of F2 upon the addition of Cu²⁺ and EDTA are applied as an ultrasensitive IMPLICATION logic gate at the mol. level. At the same time, mol. keyboard experiments have achieved information protection at the mol. level. More importantly, the test strips containing F2 can be easily and quickly tested to achieve on-site inspection.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Huang, Zheng;Song, Wei-Li;Liu, Yingjun;Wang, Wei;Wang, Mingyong;Ge, Jianbang;Jiao, Handong;Jiao, Shuqiang published 《Stable Quasi-Solid-State Aluminum Batteries》 in 2022. The article was appeared in 《Advanced Materials (Weinheim, Germany)》. They have made some progress in their research.HPLC of Formula: 65039-09-0 The article mentions the following:

Nonaqueous rechargeable aluminum batteries (RABs) of low cost and high safety are promising for next-generation energy storage. With the presence of ionic liquid (IL) electrolytes, their high moisture sensitivity and poor stability would lead to critical issues in liquid RABs, including undesirable gas production, irreversible activity loss, and an unstable electrode interface, undermining the operation stability. To address such issues, herein, a stable quasi-solid-state electrolyte is developed via encapsulating a small amount of an IL into a metal-organic framework, which not only protects the IL from moisture, but creates sufficient ionic transport network between the active materials and the electrolyte. Owing to the generated stable states at both pos.-electrode-electrolyte and neg.-electrode-electrolyte interfaces, the as-assembled quasi-solid-state Al-graphite batteries deliver specific capacity of ≈75 mA h g^-1 (with pos. electrode material loading ≈9 mg cm^-2, much higher than that in the conventional liquid systems). The batteries present a long-term cycling stability beyond 2000 cycles, with great stability even upon exposure to air within 2 h and under flame combustion tests. Such technol. opens a new platform of designing highly safe rechargeable Al batteries for stable energy storage.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.HPLC of Formula: 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline《An efficient green synthesis of 5H-spiro[benzo[4,5]imidazo[1,2-c]quinazoline-6,3′-indolin]-2′-ones catalyzed by iodine in ionic liquids》 was published in 2017. The authors were Zhang, Mei-Mei;Wang, Yue;Liu, Jian-Quan;Wang, Xiang-Shan, and the article was included in《Heterocyclic Communications》. The author mentioned the following in the article:

Benzene-1,2-diamine was treated with 2-nitrobenzaldehyde in EtOH, and the product was reduced with hydrazine hydrate in the presence of Fe(C) without separation to give 2-(1H-benzo[d]imidazol-2-yl)aniline. Reactions of compound 2-(1H-benzo[d]imidazol-2-yl)aniline with isatins in the presence of iodine in an ionic liquid furnished 5H-spiro[benzo[4,5]imidazo[1,2-c]quinazoline-6,3′-indolin]-2′-ones I [R= H, 5′-Me, 4′-Cl, 6′-Br, 7′-F, etc.] in high yields.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem