Month: September 2022

Imidazole based anticancer drug find applications in cancer chemotherapy. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Formula: C27H37ClN2.

Cesari, Cristiana;Gagliardi, Anna;Messori, Alessandro;Monti, Nicola;Zanotti, Valerio;Zacchini, Stefano;Rivalta, Ivan;Calcagno, Francesco;Lucarelli, Carlo;Tabanelli, Tommaso;Cavani, Fabrizio;Mazzoni, Rita research published 《 Boosting the guerbet reaction: A cooperative catalytic system for the efficient bio-ethanol refinery to second-generation biofuels》, the research content is summarized as follows. The catalytic activity of anionic ruthenium complexes toward the transformation of bio-ethanol to 1-butanol and higher alcs. is found to be dependent on the imidazolium counterion. After the identification of a parallel reaction involving the catalyst in hydrogen evolution, conversion and selectivity are impressively boosted by the addition of p-benzoquinones as co-catalysts. The catalytic system avoids the side reaction and led to highly competitive conversions up to 88% (0.2 % mol ruthenium catalyst loading, 1.5 % mol benzoquinone loading). Butanol and higher alcs. are produced in yields up to 85% (overall selectivity 97%) as a mixture of valuable alcs. for advanced biofuel and lubricants applications. The catalytic system can be recycled and the reaction shows comparable efficiency on a real matrix (alc. from wine production chain wastes) even in the presence of significant amounts of water, thus closing a hypothetic economic circle. A reaction mechanism is proposed for the most promising ruthenium complex working in cooperation with the most efficient co-catalyst: p-benzoquinone.

Formula: C27H37ClN2, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Category: imidazoles-derivatives.

Cervantes-Reyes, Alejandro;Farshadfar, Kaveh;Rudolph, Matthias;Rominger, Frank;Schaub, Thomas;Ariafard, Alireza;Hashmi, A. Stephen K. research published 《 Copper-catalyzed synthesis of α-alkylidene cyclic carbonates from propargylic alcohols and CO₂》, the research content is summarized as follows. A N-heterocyclic carbene copper(I) complex-catalyzed formal cycloaddition between readily available propargylic alcs. and carbon dioxide at room temp is reported. By using the combination of a sterically demanding ^BPDPrCuCl complex (^BPDPr = 1,3-bis(2,6-diisopropylphenyl)-1,3-diazonine-2-ylidene) and CsF, as catalytic system, primary propargylic alcs. are efficiently converted to the corresponding α-alkylidene cyclic carbonates. Gram scale (up to 89% yield) and reusability experiments (74% global yield, turnover number value = 103) showcase the robustness of the catalytic system. This practically simple protocol also tolerates secondary and tertiary propargylic alcs. under CO₂ at atm. pressure, enabling the direct synthesis of substituted and unsubstituted α-alkylidene cyclic carbonates at room temperature

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Recommanded Product: 1,2-Dimethyl-1H-imidazole.

Cavieres, Jenifer;Jose Inestrosa-Izurieta, Maria;Vasco, Diego A.;Urzua, Julio I. research published 《 Ionanofluids based on ionic liquid mixtures, a new approach as an alternative material for solar energy storage》, the research content is summarized as follows. Hybrid materials based on ionic liquids (ILs) known as Ionanofluids (INFs) have shown exciting improvements in their thermophys. properties compared to their base fluids (BF). Within this group, INFs obtained using mixtures of ionic liquids as BFs have been virtually ignored until now. In this work, INFs composed of two equimolar mixtures of ILs, [Omim][PF₆] + [Odmim][PF₆] and [Omim][PF₆] + [Odmim][BF₄] as base fluids and Multiwalled Carbon Nanotubes (MWCNTs) with weight percentages of 0.04, 0.06, 0.08, and 0.1 wt% were elaborated. Furthermore, the thermophys. properties of our proposed new materials were evaluated and compared to conventional materials currently used in solar energy storage systems. It was shown that the heat capacity (Cp) reaches increases of up to 3.7 and 3.2 times that of nitrated salts and the com. fluid Therminol VP-1, which translates into a 9.4% and 284% higher thermal storage d. (E), resp., and even lower thermal diffusivity (α), which supports the preliminary idea of using these new materials for energy storage.

Recommanded Product: 1,2-Dimethyl-1H-imidazole, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Name: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride.

Cauwenbergh, Thibault;Scattolin, Thomas;Simoens, Andreas;Tzouras, Nikolaos V.;Stevens, Christian V.;Nolan, Steven P. research published 《 Continuous Flow Synthesis of Sulfur- and Selenium-NHC Compounds (NHC=N-Heterocyclic Carbene)》, the research content is summarized as follows. The first continuous flow syntheses of sulfur- and selenium-NHC (NHC=N-heterocyclic carbene) adducts in unprecedented short reaction times and high yields are reported. The importance of these species in coordination chem. or as efficient tools for determining the π-acceptor character of NHC ligands make any improvement in their synthesis a worthy goal. Thiourea derivatives bearing both saturated and unsaturated NHCs were obtained using NEt3 as a weak base (homogeneous setup) in conjunction with a bed of elemental sulfur (S₈). The synthetic route proving optimal for selenoureas involves the use of a simple Se/K₂CO₃ heterogeneous microreactor design.

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., Name: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Name: 1-Methyl-1H-imidazole-2(3H)-thione.

Capan, Irfan research published 《 Methimazole Analogs as Urease Inhibitors: Synthesis, In Silico and In Vitro Evaluation》, the research content is summarized as follows. Urease plays a key role in urinary tract and gastrointestinal infections for which inhibition of it could prove to be substantial as a potential therapeutic option. Here, synthesized thirty novel compounds in four different series based on methimazole skeleton, also known as thiamazole, a drug that is used for the treatment of hyperthyroidism. Characterization of novel compounds consisting oxadiazoles, hydrazine-1-carbothioamides and N′-arylidenebenzohydrazides were performed by ¹H-, ¹³C-NMR and high resolution mass spectrometry (HRMS). The synthesized mols. were examined for structure-activity relationship in urease inhibition and found to exhibit inhibitory potency in a range of IC₅₀ =3.56-14.08 μM compared to urea and acetohydroxamic acid used as standard Moreover, mol. docking was performed to understand ligand binding interactions in the active site of the enzyme (Jack bean urease, Protein Data Bank ID 3LA4). The promise of addressing urinary tract and gastrointestinal disorders through urease inhibition is discussed.

Name: 1-Methyl-1H-imidazole-2(3H)-thione, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Synthetic Route of 10111-08-7.

Cao, Yunzhe;Mo, Fengye;Liu, Yahua;Liu, Yu;Li, Gaiping;Yu, Wenqian;Liu, Xiaoqing research published 《 Portable and sensitive detection of non-glucose target by enzyme-encapsulated metal-organic-framework using personal glucose meter》, the research content is summarized as follows. Personal glucose meter (PGM) is one of the most com. available POC (point-of-care) devices for monitoring the level of glucose reliably, yet its non-glucose quantification ability is limited since such strategy needs ingenious interface design and tedious enzyme conjugation. Herein, we constructed a portable and sensitive platform that can detect non-glucose target by combining enzyme-encapsulated zeolitic imidazole framework-90 (ZIF-90) with personal glucose meter. ZIF-90 is an ideal carrier and susceptor due to the extraordinary capability of packaging enzyme and stimuli-responsiveness. We selected adenosine-5′-triphosphate (ATP) as the target model of non-glucose analytes. Upon ATP-induced decomposition of MOF, the released enzyme (glucose oxidase or invertase) catalyzed substrate and gave rise to the change of the glucose concentration for PGM assay. This method determined ATP with a remarkably sensitivity of 233 nM and effective recovery in real serum samples. Our strategy provides a facile and practical approach for measuring the non-glucose target using PGM, and could potentially be applied in bimol. detection in point-of-care diagnosis.

Synthetic Route of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . SDS of cas: 10111-08-7.

Cao, Xiang-Xin;Liu, Shui-Li;Lu, Jing-Sheng;Zhang, Zhen-Wei;Wang, Gang;Chen, Qing;Lin, Ning research published 《 Chitosan coated biocompatible zeolitic imidazolate framework ZIF-90 for targeted delivery of anticancer drug methotrexate》, the research content is summarized as follows. In this work, using zeolitic imidazolate framework (ZIF) as carrier, a new biocompatible anti-cancer drug delivery system CS@MTX@ZIF-90 (CMZ) was efficiently synthesized by one-pot method. Methotrexate (MTX), an anticancer drug as folic acid analog was loaded into ZIF-90 through Schiff base reaction between amino group in MTX and aldehyde group of imidazole-2-carboxaldehyde ligand with drug loading amount about 250 mg/g. As a pH-sensitive biomaterial, chitosan (CS) was modificated by the outer layer of the particles to improve the pH responsiveness of the composite CMZ during the drug release process. By releasing a large amount of MTX under acidic conditions (the pH environment around tumor cells), and releasing a substantially lower amount of MTX at a normal environment, CMZ exhibited a pH-responsive and target-selective behavior. In addition, in vitro cytotoxicity and anticancer activity results showed that CMZ can inhibit the growth of liver cancer HepG2 cells, prostate cancer DU145 cells and gastric cancer SGC7901 cells, with only negligible toxicity to normal EC304 cells. Based upon the results of corresponding experiments, CMZ exhibited high MTX drug loading, cancer-targeted release and good biocompatibility, which can be used as a good candidate for anticancer drug delivery system.

SDS of cas: 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Synthetic Route of 1739-84-0.

Cao, Liming;Gong, Zhou;Xu, Chuanhui;Chen, Yukun research published 《 Mechanical Strong and Recyclable Rubber Nanocomposites with Sustainable Cellulose Nanocrystals and Interfacial Exchangeable Bonds》, the research content is summarized as follows. Rubber is a strategically important polymeric material because of its high extensibility and resilience. However, traditional crosslinked rubber is difficult to be reprocessed or recycled due to the permanent covalent crosslinking, which puts a huge burden on the environment. Herein, we report a covalently crosslinked yet reprocessable carboxylated styrene butadiene rubber (CSBR) nanocomposite which is reinforced and crosslinked by epoxy-modified tunicate cellulose nanocrystals (TCNCs). The epoxy modification of TCNCs improves the dispersibility and the interfacial interactions with the matrix, thus improving the mech. properties of the nanocomposites. In addition, exchangeable ester bonds are formed at the rubber-filler interface, and the network topol. can be rearranged via the transesterification reactions. Therefore, the materials can be reprocessed and recycled under the evaluated temperatures In particular, by introducing metal coordination bonds to construct a dual dynamic network in the system, the mech. properties of the nanocomposites can be further improved without compromising the recycling and reprocessing performance.

1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., Synthetic Route of 1739-84-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Name: 1,2-Dimethyl-1H-imidazole.

Cao, Lei;Kim, Hong Won;Jeong, Yu Jin;Han, Seung Chang;Park, Jin Kyoon research published 《 Rapid Continuous-Flow Water-Free Synthesis of Ultrapure Ionic Liquids Assisted by Microwaves》, the research content is summarized as follows. A wide range of imidazole, pyridine including insoluble polymers, and tertiary amine derivatives rapidly reacted with orthoformate using various Bronsted acids or ammonium salts to control the anionic parts. The corresponding ionic liquids were formed in excellent yields under microwave-batch conditions within 10 min. A scale-up synthesis was easily achieved using a microwave flow system. Typically, [BMIM][BF₄] was produced at a rate of 26.2 g/h under an Ar atm. with an E-factor of 0.8. Both batch and flow experiments were also performed in a domestic microwave oven.

1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., Name: 1,2-Dimethyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem