September 2022 - Page 11 of 33 - Imidazoles-derivatives

Basappa Chidananda, Vasantha Kumar et al. published new experimental results with the assistance of cas: 5805-39-0

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Related Products of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Related Products of 5805-39-0《Benzimidazolyl based Schiff base palladium complex in an ionic liquid: an effective combination for Suzuki coupling》 was published in 2017. The authors were Basappa Chidananda, Vasantha Kumar;Ramakrishna, Dileep;Kaur, Manpreet;Hosakere Doddarevanna, Revanasiddappa, and the article was included in《Journal of Coordination Chemistry》. The author mentioned the following in the article:

A new benzimidazole based Pd(II) Schiff base complex (I) was prepared and its catalytic activity was evaluated for Suzuki cross-coupling reactions in ethyl-Me imidazolium hexafluorophosphate [EMIM PF₆] ionic liquid at ambient temperature The system provides a stable and reusable method for coupling reactions. Optimization for suitable reaction conditions were studied with respect to the effect of catalyst concentration, effects of additives, solvent and substituents on boronic acid. Good to excellent yields were achieved using a modest amount of the catalyst. The reaction time was less and the yield was more compared to previously reported results. In addition, the catalyst can be easily reused and recycled for six times without much loss in activity; this is an example of sustainable and green methodol. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Frawley, Rachel P. et al. published new experimental results with the assistance of cas: 65039-09-0

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Name: 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Frawley, Rachel P.;Germolec, Dori R.;Johnson, Victor J.;Gulledge, Travis;Manheng, Wimolnut;White, Kimber Jr.;Shockley, Keith R.;Harris, Shawn F.;Hooth, Michelle;Ryan, Kristen published 《Evaluation of skin sensitization induced by four ionic liquids》 in 2022. The article was appeared in 《Journal of Applied Toxicology》. They have made some progress in their research.Name: 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride The article mentions the following:

Ionic liquids (ILs) are synthetic solvents used as replacements for volatile organic solvents. Human exposure occurs through dermal or oral routes. In rodents, several ILs were reported to induce dermal toxicity, irritation, and sensitization. Due to the potential for occupational exposure, and industrial use as nonvolatile solvents, 1-ethyl-3-methylimidazolium chloride (EMIM, 6.25% to 50% volume/volume), 1-butyl-3-methylimidazolium chloride (BMIM, 3.12% to 12.5% volume/volume), 1-butyl-1-methylpyrrolidinium chloride (BMPY, 0.825% to 6.25% volume/volume), and N-butylpyridinium chloride (NBuPY, 0.825% to 12.5% volume/volume) were nominated to the National Toxicol. Program and evaluated for skin sensitization. The test compound was applied to the ears of female BALB/c mice daily for 3 days in a primary irritancy (IRR)/local lymph node assay (LLNA). Sensitization was assessed in vitro in the direct peptide reactivity assay (DPRA), KeratinoSens assay, and human cell line activation test (h-CLAT). In the LLNA, the butylated ILs, BMIM, and BMPY were more potent than NBuPY (butylated) or EMIM (ethylated), which was neither an irritant nor a sensitizer. NBuPY induced skin irritation in vivo at ≥3.12% (p ≤ 0.01), and sensitization in vitro in the KeratinoSens assay and h-CLAT, but was neg. for sensitization in vivo and in the DPRA. Although SI3 was not achieved, dermal treatment with 12.5% BMIM or 6.25% BMPY increased (p ≤ 0.01) lymph node cell proliferation in the LLNA. In vitro, BMIM was pos. for sensitization in the h-CLAT, and BMPY was pos. in the h-CLAT and KeratinoSens assay; both were neg. in the DPRA. Integrated data analyses, weighted toward in vivo data, suggested that BMIM and BMPY may induce weak to mild sensitization. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cas: 65039-09-0 | Rahmani, Farzinpublished an article in 2022

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Related Products of 65039-09-0

Rahmani, Farzin;Pasquinelli, Melissa A. published 《Molecular Insights into the Interfacial Properties of Cellulose Surfaces with Varying Types of Ionic Liquid Epoxies》. The research results were published in《ACS Applied Polymer Materials》 in 2022.Related Products of 65039-09-0 The article conveys some information:

Due to the excellent physio-chem. and mech. properties, ionic liquid epoxies (ILE) can serve as a perfect material for various technologies along with many other materials as a substrate. In this study, we employed mol. dynamics simulations to gain fundamental mol. insights about a conventional epoxy and an imidazolium-based ILE and how adhesion on crystalline cellulose surfaces is affected by crosslinking and the type of ionic liquid (IL) counter anions (e.g. [OAc], [Cl], and [TF₂N]) on thermo-mech. and moisture absorption of bulk ILE were further investigated. When comparing the ILE/cellulose systems vs. bulk ILE systems, the results indicate that the presence of a cellulose surface lowers the degree of crosslinking due to the adsorption of the hardener on its surface. Overall, the ILEs/cellulose exhibit a higher interfacial bonding energy than conventional epoxy/cellulose. Improved adhesion is significant for hydrophilic ILEs, which is likely attributed to hydrogen bonds formed between the cellulose and anion mols. This computational study provides mol.-level insights into the adsorption mechanism of ILE onto a crystalline cellulose surface, leading to the design of smart and multifunctional thermoset adhesives. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cas: 5805-39-0 | Xu, Mengyu et al. made new progress in 2020

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Category: imidazoles-derivatives) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Category: imidazoles-derivatives《High accuracy machine learning identification of fentanyl-relevant molecular compound classification via constituent functional group analysis》 was published in 2020. The authors were Xu, Mengyu;Wang, Chun-Hung;Terracciano, Anthony C.;Masunov, Artem E.;Vasu, Subith S., and the article was included in《Scientific Reports》. The author mentioned the following in the article:

Fentanyl is an anesthetic with a high bioavailability and is the leading cause of drug overdose death in the U. S. Fentanyl and its derivatives have a low LD and street drugs which contain such compounds may lead to death of the user and simultaneously pose hazards for first responders. Rapid identification methods of both known and emerging opioid fentanyl substances is crucial. In this effort, machine learning (ML) is applied in a systematic manner to identify fentanyl-related functional groups in such compounds based on their observed spectral properties. In our study, accurate IR (IR) spectra of common organic mols. which contain functional groups that are constituents of fentanyl is determined by investigating the structure-property relationship. The average accuracy rate of correctly identifying the functional groups of interest is 92.5% on our testing data. All the IR spectra of 632 organic mols. are from National Institute of Standards and Technol. (NIST) database as the training set and are assessed. Results from this work will provide Artificial Intelligence (AI) based tools and algorithms increased confidence, which serves as a basis to detect fentanyl and its derivatives The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xie, Yanyan et al. published new progress in experiments with the help of cas: 65039-09-0

SDS of cas: 65039-09-0In 2022, Xie, Yanyan;Gao, Hongshuai;Zhang, Puyu;Qin, Congwen;Nie, Yi;Liu, Xue published 《Preparation of Degradable Wood Cellulose Films Using Ionic Liquids》. 《ACS Applied Polymer Materials》published the findings. The article contains the following contents:

Biodegradable films prepared from cellulose have been developed in recent years. In this work, six kinds of wood cellulose films (WCFs) were successfully prepared using wood cellulose as raw materials and six ionic liquids (ILs) as solvents. The structure and properties of WCFs produced using six imidazole-based and 1,5-diazabicyclo[4.3.o]non-5-ene (DBN)-based ILs were investigated systematically. It indicated that the WCFs produced from 1-ethyl-3-methylimidazolium di-Et phosphate ([Emim]DEP) had a maximum transmittance of 90.1% and tensile strength of 124.5 MPa, which were much higher than the counterparts to 26.2% and 42.0 MPa of the WCFs produced using DBN-based ILs. Moreover, the structure and properties of WCFs and ILs had a little change after five recycles. Based on that, we used the screened [Emim]DEP as a solvent to prepare a highly efficient UV-to-red light conversion cellulose film (LCF) by doping rare-earth light-converting particles, CaAlSiN₃:Eu²⁺ (CASN). Results showed that the LCF emitted red light at 640 nm and had excellent light conversion ability, which was conducive to photosynthesis.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New progress of cas: 65039-09-0 | Chemical Engineering Science 2022

Liu, Chenyi;Ling, Yijie;Wang, Zhennan;Zheng, Weizhong;Sun, Weizhen;Zhao, Ling published 《Unveiling the microenvironments between ionic liquids and methanol for alcoholysis of poly(ethylene terephthalate)》. The research results were published in《Chemical Engineering Science》 in 2022.Synthetic Route of C6H11ClN2 The article conveys some information:

Ionic liquids (ILs) have proved to be efficient catalysts for the alcoholysis of poly(ethylene terephthalate) (PET). However, the in-depth understanding about the alcoholysis of PET at a mol. level remains scarce. Herein, the microstructures and dynamics of ILs/methanol systems with and without PET oligomer were investigated using mol. dynamics (MD) simulations. A better miscibility between [OAc]-containing ILs and methanol is observed There exist hydrogen-bonding networks between cation, anion, and methanol, in which the cation serves as a donor and methanol as an acceptor, while the anion/methanol hydrogen-bonding interaction follows the opposite donor-acceptor relationship. In ILs/methanol/PET ternary systems, the hydroxyl groups of [Cho] cations display a more significant interaction with carbonyl groups of PET oligomer than [Emim] cations. In addition, PET oligomer diffuses quite faster in [Cho][OAc] compared to [Emim][OAc]. The information obtained in this work is helpful to better understand the mechanism of the PET alcoholysis process.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cas: 65039-09-0 was involved in experiment | Crystals 2022

Deyko, Gregory S.;Glukhov, Lev M.;Isaeva, Vera I.;Chernyshev, Vladimir V.;Vergun, Vadim V.;Archipov, Danil A.;Kapustin, Gennady I.;Tkachenko, Olga P.;Nissenbaum, Vera D.;Kustov, Leonid M. published 《Modifying HKUST-1 Crystals for Selective Ethane Adsorption Using Ionic Liquids as Synthesis Media》 in 2022. The article was appeared in 《Crystals》. They have made some progress in their research.Application In Synthesis of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride The article mentions the following:

Novel adsorbents for methane and ethane based on HKUST-1 metal-organic framework were synthesized by microwave (MW) assisted technique using ionic liquids (ILs) as synthesis media. It was found that the MW synthesis time remarkably impacts both the product yield and the physico-chem. characteristics of the produced HKUST-1 material. The crystalline phase purity, crystallite size/dispersion and textural properties of the synthesized HKUST-1 matrixes determine their performance in methane and ethane adsorption. Therefore, the HKUST-1 material produced in MW fields for 3 min only shows the highest phase purity and the largest surface area (BET) and porosity, along with a rather small crystallite size (below ∼300 nm), demonstrating high methane and ethane adsorption capacity in the pressure range 1-30 atm. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

ACS Applied Materials & Interfaces | Cas: 65039-09-0 was involved in experiment

Wu, Gaohong;Lv, Wenrong;Li, Xiaoxiao;Zhang, Wenming;Li, Zhanyu published 《Metal-Organic Framework Structure with Fe-Co-Se (MIL-88A/Fe-Co@Se) as a Cathode for Aluminum Batteries》 in 2021. The article was appeared in 《ACS Applied Materials & Interfaces》. They have made some progress in their research.Electric Literature of C6H11ClN2 The article mentions the following:

Rechargeable aluminum-ion batteries have received more and more attention because of their high theor. energy d., high safety, and reasonable price. The cathode material of aluminum batteries is one of the key bottlenecks that limits their development. Although there are many reports on aluminum battery cathode materials, many of these reports fail to simultaneously solve the poor cycling stability and low specific capacity of aluminum batteries. Therefore, we formed YSNT@Se hybrids by compounding the MOFs-MIL-88A@Fe-Co hydroxide yolk-shell nanotubes (YSNTs) with selenium for the first time. It was finally determined that the FeSe₂ in YSNT@Se is the main redox reaction participant during charging/discharging. In the charge/discharge of YSNT@Se 500°C, it achieved a first cycle discharge specific capacity of 292.21 mA h g^-1. After 500 cycles, the discharge capacity was 233.34 mA h g^-1 and the capacity retention rate reached 79.85%. This result proves that the redox process is highly reversible at the same time. This work makes it possible for aluminum batteries to have a high cycling performance and a high capacity and broadens the research direction of cathode materials for aluminum batteries. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jonsson, Helgi Freyr team published research on Dalton Transactions in 2021 | 250285-32-6

Application In Synthesis of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Application In Synthesis of 250285-32-6.

Jonsson, Helgi Freyr;Fiksdahl, Anne;Harvie, Andrew J. research published 《 Rapid and mild synthesis of Au-NHC complexes in a simple two-phase flow reactor》, the research content is summarized as follows. We describe a simple two-phase flow reactor which allows for the rapid synthesis of several Au(I)-NHC complexes in high yields (>88%), under mild conditions, and with minimal workup. Translation of the standard weak base method to a two-phase flow reaction prevents the common problem of decomposition to Au(0). The reaction can be scaled up more than ten-fold without loss in conversion efficiency. An optional second stage allows for direct synthesis of Au(III)-NHC complexes, without isolation of the Au(I)-NHC intermediate, with a two-step isolated yield of 82%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Johnson, Chloe team published research on ChemCatChem in 2021 | 250285-32-6

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. COA of Formula: C27H37ClN2.

Johnson, Chloe;Dabral, Saumya;Rudolf, Peter;Licht, Ulrike;Hashmi, A. Stephen K.;Schaub, Thomas research published 《 Liquid-liquid-phase Synthesis of exo-Vinylene Carbonates from Primary Propargylic Alcohols: Catalyst Design and Recycling》, the research content is summarized as follows. A straight-forward approach to sep. catalyst from the exo-vinylene carbonate (EVC) products of the carboxylative cyclisation of primary propargylic alcs. has been developed. The liquid-liquid phase synthesis utilizes lipophilic silver(I) carboxylate salts and N,N-dioctyl modified phosphine (FatPhos) ligands to enhance catalyst solubility in non-polar solvents. Following simple liquid-liquid phase separation, EVCs relevant as monomers for poly(urethane) and poly(carbonate) synthesis were isolated in the non-miscible polar phase in good yields. In situ reaction monitoring by ReactIR gave insights into the reaction kinetics and informed the conditions used to afford good EVC selectivity. Under optimized conditions, silver leaching into the product phase was very minor as confirmed by ICP-MS. Furthermore, a protocol for catalyst recycling by liquid-liquid separation was demonstrated, with modest loss of catalytic activity over 3 runs.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem