Month: September 2022

Category: imidazoles-derivatives《A porous thienyl cyclodextrin polymer synthesized in a homogeneous ionic liquid catalytic system for the rapid removal of pharmaceuticals and personal care products (PPCPs)》 was published in 2022. The authors were Tu, Yizhou;Wang, Huimin;Yang, Pingping;Xu, Guizhou;Hu, Xuejiao;Li, Aimin;Xie, Xianchuan, and the article was included in《Green Chemistry》. The author mentioned the following in the article:

Pharmaceuticals and personal care products (PPCPs) are widely distributed in aquatic environments due to their large consumption and low biodegradability, causing ecol. risks. In this study, a porous thienyl cyclodextrin polymer (Th-CDP) with a sp. surface area of 730 m² g^-1 was synthesized in an ionic liquid system for the first time to remove PPCPs. The green and recyclable 1-ethyl-3-methylimidazolium chloride/ferric chloride ([EMIm]Cl/FeCl₃) ionic liquid was synthesized as a solvent and catalyst, superior to traditional toxic organic solvents and heterogeneous catalysts. In Th-CDP synthesis, thienyl cyclodextrin (ThCD) was synthesized, followed by polymerization with the three-dimensional crosslinking agent tri-Me orthoformate (Tmof) in [EMIm]Cl/FeCl₃ via the Friedel-Crafts alkylation reaction. Th-CDP shows excellent adsorption towards the studied PPCPs (diclofenac, ibuprofen, carbamazepine, and sulfamethoxazole) due to the rich pore structure. In particular, Th-CDP achieved 90% removal of hydrophobic diclofenac and ibuprofen in 5 min, and the rate constants were 16.7 and 10.5 times higher than those of activated carbon, resp. The adsorption capacity of Th-CDP is related to the mol. weight and pKa of the compound, and is about twice that of activated carbon. Th-CDP has more pronounced adsorption advantages over activated carbon for acidic compounds due to its pos. charge under neutral conditions. In addition, multiple mechanisms, including hydrophobic interaction caused by thiophene and cyclodextrin, electrostatic interaction, and heteroatom interaction (24.8% S content), enable Th-CDP to efficiently remove PPCPs. Moreover, Th-CDP has great application potential due to its excellent regenerability, anti-interference ability, and green synthesis process. The experimental procedure involved many compounds, such as 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Category: imidazoles-derivatives

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Shaikh, Irfan N.;Bagwan, Umar Farooq;Hunagund, Shirajahammad M.;Shaikh, Imran N.;Afzal, Mohammed published 《Cu-catalyzed Rapid Synthesis of Novel Fluorinated Indole Derivatives Under Microwave Irradiation》 in 2018. The article was appeared in 《Chemistry Africa》. They have made some progress in their research.Product Details of 5805-39-0 The article mentions the following:

Herein, a simple microwave-assisted synthesis of novel fluorinated indole derivatives I [R = (1H-benzimidazol-2-yl)phenyl, 6-chloro-7H-purin-2-yl, 3-amino-2,2-dimethyl-3-phenylpropyl, etc.] have been developed by the reaction of 5-fluoroindoline-2,3-dione with various anilines RNH₂. The reaction could be conducted using readily available substrates within short periods of 9-15 min under microwave irradiation with good to excellent yields of the product (64-92%). This approach exploits the synthetic potential of microwave irradiation and copper dipyridine dichloride (CuPy₂Cl₂) combination and offers many advantages such as full reaction control, excellent product yields, shorter reaction time, eco-friendly procedure and rapid feedback. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Product Details of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Category: imidazoles-derivativesIn 2019, Li, Jia-Bin;Liu, Yang;Zheng, Xiang-Jun;Wang, Dan published 《An off-on chemosensor for Hg²⁺ based on the excimer emission of anthracene》. 《Microchemical Journal》published the findings. The article contains the following contents:

A quinazoline derivative 6-anthracenyl-5,6-2H-benzimidazo[1,2-c]quinazoline (L) was obtained and characterized by elemental anal., IR spectroscopy, ¹H NMR and single-crystal X-ray diffraction. L shows very weak emission in DMSO, but can respond to Hg²⁺ ion intensively in off-on mode. Job’s plot and titration experiments show that Hg²⁺ ion binds L in 1:1 stoichiometry. The detection limit for Hg²⁺ is 6.34μM. ¹H NMR titration experiments indicate that only one benzimidazo nitrogen atom coordinates with Hg2+. And the fluorescence emission spectra imply that an excimer formed in the Hg²⁺-L system, and the detection of Hg²⁺ was realized by excimer emission of anthracene moiety. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Category: imidazoles-derivatives) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Odame, Felix;Hosten, Eric C. published 《Synthesis, characterization and computational studies of two triazaspiro tetracycles》 in 2018. The article was appeared in 《Acta Chimica Slovenica》. They have made some progress in their research.Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

Synthesis of two new triazaspiro tetracycles I (R = 3-Me, 4-Me) and their characterization using spectroscopy, microanal. and single crystal X-ray diffractometry are discussed. The DFT computed bond angles were obtained for both compounds and compared to exptl. results for the compound I (R = 4-Me). The HOMO-LUMO anal. of both compounds has been carried out. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xie, Caixia;Zhang, Zeyuan;Li, Danyang;Gong, Jian;Han, Xushuang;Liu, Xuan;Ma, Chen published 《Dimethyl Sulfoxide Involved One-Pot Synthesis of Quinoxaline Derivatives》. The research results were published in《Journal of Organic Chemistry》 in 2017.Synthetic Route of C13H11N3 The article conveys some information:

An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines is reported herein. DMSO was used as both a reactant and a solvent in this reaction. A wide range of products in moderate to excellent yields were obtained, including pyrrolo[1,2-a]quinoxalines, indolo[1,2-a]quinoxalines, 1H-pyrrolo[3,2-c]quinolines, and benzo[4,5]imidazo[1,2-c]quinazolines. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Synthetic Route of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Meng, Pengyu;Huang, Jian;Yang, Zhaohui;Wang, Fei;Lv, Teng;Zhang, Jiao;Fu, Chaopeng;Xiao, Wei published 《A Low-Cost and Air-Stable Rechargeable Aluminum-Ion Battery》 in 2022. The article was appeared in 《Advanced Materials (Weinheim, Germany)》. They have made some progress in their research.Product Details of 65039-09-0 The article mentions the following:

Rechargeable aluminum-ion batteries (AIBs) are promising for large-scale energy storage due to the abundant reserves, low cost, and high capacity of the Al anode. However, the development of AIBs is currently hindered by the usage of AlCl₃/1-ethyl-3-methylimidazolium chloride electrolyte, which is expensive, highly corrosive, and extremely air-sensitive. Herein, a new hydrated eutectic electrolyte (HEE) composed of hydrated aluminum perchlorate and succinonitrile for low-cost, noncorrosive, and air-stable AIBs is reported. Crystal water in the hydrated aluminum perchlorate plays a vital role in forming the HEE, in which one H₂O and five succinonitrile mols. coordinate with one Al³⁺ ion. The optimized ratio of Al(ClO₄)₃·₉H₂O to succinonitrile is 1:12. When combining with the self-doped polyaniline cathode, the associated AIB delivers a high discharge capacity of 185 mAh g^-1 over 300 cycles; and the charge/discharge mechanism in the HEE is studied exptl. and theor. The HEE is nonflammable, air-stable, and noncorrosive, thus enabling good air tolerance and facile fabrication of AIBs. To complete the study, the researchers used 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Product Details of 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Liu, Zhuo;Cheng, Hanlin;Le, Qiujian;Chen, Rui;Li, Jianbo;Ouyang, Jianyong published 《Giant Thermoelectric Properties of Ionogels with Cationic Doping》. The research results were published in《Advanced Energy Materials》 in 2022.HPLC of Formula: 65039-09-0 The article conveys some information:

Although ionic thermoelec. (iTE) materials can have very high thermopower, it is of great significance to develop novel methods to further improve the ionic thermopower and figure of merit (ZTi). Here, significant improvement in the thermopower and thus the ZTi value of an ionogel by cationic doping, is reported. Doping sodium dicyanamide (Na:DCA) into the ionogels of poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and 1-ethyl-3-methylimidazolium dicyanamide (EMIM:DCA) that is an ionic liquid can greatly enhance the thermopower. This is attributed to the interactions between the doped Na+ cations and DCA- anions, thereby increasing the difference in the mobilities of EMIM+ cations and DCA- anions. Moreover, through the combination with the solid networks engineering by an anti-solvent to PVDF-HFP, the PVDF-HFP/EMIM:DCA ionogel doped with 0.5 mol% Na+ with respect to EMIM+ exhibits an ionic thermopower of 43.8 ± 1.0 mV K-1, ionic conductivity of 19.4 ± 0.3 mS cm^-1 and thermal conductivity of 0.183 W m-1 K-1 at the relative humidity of 85% and room temperature The corresponding ZTi value thus reaches 6.1 ± 0.4, much higher than the previous ZTi records of iTE materials. These ionogels can be used in the iTE capacitors for the thermoelec. conversion.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.HPLC of Formula: 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Soheilmoghaddam, Farhad;Sharifzadeh, Ghorbanali;Adelnia, Hossein;Wahit, Mat Uzir published 《Development of Regenerated Cellulose/Citric Acid Films with Ionic Liquids》 in 2022. The article was appeared in 《Journal of Polymers and the Environment》. They have made some progress in their research.Category: imidazoles-derivatives The article mentions the following:

Nowadays, the importance of green and biodegradable plastics as viable substitutes for non-degradable petroleum-based materials is felt more than ever. Regenerated cellulose (RC) as a potential candidate suffers from poor processability and inferior properties, limiting its wide applications. In this study, it is demonstrated that citric acid (CA) enhances phys., mech., and thermal properties of RC films, due to RC-citric acid compatibility. 1-Ethyl-3-methylimidazolium chloride (EMIMCl) as a green ionic liquid was employed for the processing of RC. The optimum properties in terms of thermal stability, mech. strength, contact angle, water uptake, and oxygen permeability were achieved at 10 wt% of CA. However, further incorporation of CA adversely affected the film properties. This behavior was explained by the crosslinking and plasticizing effects of CA. Furthermore, in vitro cytotoxicity test demonstrated that RC/CA films are cytocompatible, suggesting the potential advantage of using these biopolymeric films for biomaterial and biol. applications.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Category: imidazoles-derivatives

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product Details of 65039-09-0In 2022, Zhang, Huan;Vicent-Luna, Jose Manuel;Tao, Shuxia;Calero, Sofia;Jimenez Rioboo, Rafael J.;Ferrer, Maria Luisa;del Monte, Francisco;Gutierrez, Maria Concepcion published 《Transitioning from Ionic Liquids to Deep Eutectic Solvents》. 《ACS Sustainable Chemistry & Engineering》published the findings. The article contains the following contents:

Ionic liquids (ILs) and deep eutectic solvents (DESs) have been lately the solvent of choice in number of processes because they offer a valid alternative to conventional solvents. Despite main interactions in ILs differ from those in DESs (e.g., electrostatic-type in the former and H-bond-type in the latter), these two neoteric solvents are more closely related that appeared and can be seen as the two sides, the face and the cross, of the same coin. Herein, we hypothesized about a way for transitioning from one to the other. In particular, we promoted the transition from 1-Ethyl-3-methylimidazolium chloride (EMIMCl) to EMIMCl·nAcOH-based DESs by the simple addition of stoichiometric amounts of acetic acid (AcOH) to EMIMCl. ¹H NMR spectroscopy and DSC confirmed the occurrence of such a transition. Mol. dynamics (MD) simulations revealed the Cl anion capability to fully accommodate up to 4 AcOH mols. (e.g., EMIMCl·AcOH, EMIMCl·2AcOH, EMIMCl·3AcOH, and EMIMCl·4AcOH) without sign of H-bond self-interactions between AcOH mols. These DESs also exhibited quite different solvent properties, with α and β Kamlet-and-Taft-parameters that differed from those of EMIMCl and 1-Ethyl-3-methylimidazolium acetate (EMIMOAc). Interestingly, excess molar volume and excess viscosity measurements as well as Brillouin spectroscopic experiments indicated that aqueous dilutions of EMIMCl·AcOH-based DESs deviated from ideality as consequence of the formation of HB between water mols. and the anion, and observed by ¹H NMR spectroscopy. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Product Details of 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 5805-39-0《4-Chloro-2-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)phenol (HL); synthesis, characterization, crystal structure, Hirshfeld surface analysis and BSA binding studies》 was published in 2018. The authors were Kumar, B. C. Vasantha;K, Savithri;Chandra;Kaur, Manpreet;Jasinski, Jerry P.;Revanasiddappa, H. D., and the article was included in《Journal of Molecular Structure》. The author mentioned the following in the article:

A new asym. bidentate Schiff-base mol. 4-chloro-2-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)phenol (HL), has been synthesized and characterized using physicochem. and spectroscopic techniques, single crystal X-ray diffraction and Hirshfeld surface anal. Crystal structure anal. reveals that the compound crystallized in the orthorhombic system in the Pbca space group. The in vitro interactions of the synthesized compound, with bovine serum albumin was thoroughly investigated using UV-Vis absorption in combination with fluorescence quenching techniques, and these methods were used to determine the binding parameters also the mechanism of interaction behind the new compound HL bound to BSA. Values of the binding constants (K_b) were about ∼105 M^-1 signifying a moderate interaction between HL and BSA making the protein suitable for transportation and delivery of the compound Thermodn. parameters also revealed binding through weak van der Waals forces and hydrogen bonding interactions of HL to BSA. The results obtained from docking studies were consistent and complemented those derived from other exptl. studies. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem