Category: imidazoles-derivatives《A fluorescent chemosensor for the sequential detection of copper(II) and histidine and its biological applications》 was published in 2016. The authors were Wang, Dan;Zheng, Jian-Quan;Zheng, Xiang-Jun;Fang, De-Cai;Yuan, Da-Qiang;Jin, Lin-Pei, and the article was included in《Sensors and Actuators, B: Chemical》. The author mentioned the following in the article:
A new fluorescent sensor 6-(2,3-dihydroxyphenyl)-5,6-dihydrobenzoimidazo[1,2-c] quinazoline (H2L) and the Zn(II) complex [Zn2L12]·C2H5OH (H2L1 = 3-{[2-(1H-benzoimidazol-2-yl)-phenylimino]-methyl}-benzene-1,2-diol) (1) were synthesized and characterized by single-crystal X-ray diffraction. H2L can be used to recognize Cu2+ in aqueous media as an on-off fluorescent sensor, forming the Cu(II) Schiff-base complex (CuL1). Furthermore, CuL1 can serve as an off-on fluorescent sensor to detect histidine (His) via the ligand displacement approach. The sequential detection of Cu(II) and histidine shows on-off-on phenomenon. The crystal structure of the dinuclear Zn(II) complex indicates that the coordination of H2L with Zn(II) promotes C-N bond breakage, resulting in the quinazoline ring-opening of H2L to form the Zn(II) Schiff-base complex (1). The exptl. results proved that H+ can also assist the ring-opening of H2L to form a Schiff base, H2L1. H2L is stable in neutral and weak basic solutions This is further confirmed by the theor. calculations The cell imaging studies indicated that H2L and CuL1 can be used to detect the intracellular Cu2+ ion and His under physiol. conditions, resp. CuL1 can also be used to determine His in urine. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.
2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Category: imidazoles-derivatives) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem