Recommanded Product: 5805-39-0《4-Chloro-2-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)phenol (HL); synthesis, characterization, crystal structure, Hirshfeld surface analysis and BSA binding studies》 was published in 2018. The authors were Kumar, B. C. Vasantha;K, Savithri;Chandra;Kaur, Manpreet;Jasinski, Jerry P.;Revanasiddappa, H. D., and the article was included in《Journal of Molecular Structure》. The author mentioned the following in the article:
A new asym. bidentate Schiff-base mol. 4-chloro-2-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)phenol (HL), has been synthesized and characterized using physicochem. and spectroscopic techniques, single crystal X-ray diffraction and Hirshfeld surface anal. Crystal structure anal. reveals that the compound crystallized in the orthorhombic system in the Pbca space group. The in vitro interactions of the synthesized compound, with bovine serum albumin was thoroughly investigated using UV-Vis absorption in combination with fluorescence quenching techniques, and these methods were used to determine the binding parameters also the mechanism of interaction behind the new compound HL bound to BSA. Values of the binding constants (Kb) were about ∼105 M-1 signifying a moderate interaction between HL and BSA making the protein suitable for transportation and delivery of the compound Thermodn. parameters also revealed binding through weak van der Waals forces and hydrogen bonding interactions of HL to BSA. The results obtained from docking studies were consistent and complemented those derived from other exptl. studies. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .
2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem