Korrapati, Suresh Babu;Yedla, Poornachandra;Pillai, Girinath G.;Mohammad, Faruq;Ch., Venkata Ramana Reddy;Bhamidipati, Pranav;Amanchy, Ramars;Syed, Riyaz;Kamal, Ahmed published 《In-silico driven design and development of spirobenzimidazo-quinazolines as potential DNA gyrase inhibitors》. The research results were published in《Biomedicine & Pharmacotherapy》 in 2021.Quality Control of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article conveys some information:
DNA gyrase and Topoisomerase IV are promising antibacterial drug targets as they regulate bacterial DNA replication and topol. In a quest for novel DNA topoisomerase inhibitors, a multidisciplinary approach was adopted that involves computational prediction of binding sites and mol. modeling followed by green synthesis and biol. evaluation of antibacterial activity of spirobenzimidazo quinazolines derivatives Using basic quantum chem. principles, we evaluated spirobenzimidazo quinazolines derivatives with their pharmacokinetic profiles. Based on the results of the aforesaid in-silico studies, we synthesized a series of titled compounds using green synthetic methodol. that were validated as potential antimicrobial agents. Quantum chemoinformatics based predicted activity for the synthesized compounds 9b, 9c, and 9j was concomitant with biol. evaluation of broadspectrum antibacterial activity. Biol. evaluation revealed that inhibition of biofilm formation was due to their potential antibacterial activity. We believe that the novel spirobenzimidazo quinazolines have the potential to be alternatives to aminocoumarins and classical quinazolines upon detailed target specific biol. studies. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .
2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Quality Control of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem