Imidazole based anticancer drug find applications in cancer chemotherapy. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Product Details of C5H8N2.
Guo, Shuai;Liu, Lidong;Guo, Xin;Liu, Tiecheng;Li, Xingcan;Li, Guangyu research published 《 Unveiling the mechanism of NOx precursor formation during sewage sludge pyrolysis: Effects of carbohydrate-protein interactions》, the research content is summarized as follows. Municipal sewage sludge poses environmental and health risks, and thus, requires proper disposal using pyrolytic techniques. However, these techniques are hindered by the production of NH3 and HCN (NOx precursors) by the sludge. Hence, a comprehensive understanding of NH3 and HCN formation during sludge pyrolysis is required to minimize its NOx footprint. As sludge N mainly occurs in proteins forms, its transformations can be modeled using amino acids. Here, we aimed to the study the mechanism by which carbohydrates influence the formation of NOx precursors during sludge protein pyrolysis at different temperatures using glutamic acid, tyrosine, and histidine as protein models and cellulose and lignin as carbohydrate models. During pyrolysis, the release of NH3 and HCN was promoted by high temperatures and inhibited by carbohydrates. Despite this inhibitory effect, the results suggested that the release of NH3 should be considered for samples rich in aliphatic amino acids. For glutamic acid and tyrosine, NOx precursor formation was inhibited by N fixation in coke under the action of volatiles produced during carbohydrate pyrolysis. For glutamic acid, adding cellulose and lignin increased the coke-N content by 25.32% and 44.73% at 700°C. For histidine, this effect was ascribed to the ring-opening reactions induced by the free radical products of carbohydrate decomposition and the enhanced transfer of N-containing compounds to tar after ring-opening recombination. Further, heterocyclic-N within tar increased to 69.12% due to lignin-histidine interactions at 700°C. The results of this study can assist in regulating sludge protein pyrolysis intended for minimizing the production of NOx precursors.
Product Details of C5H8N2, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem