Martinez-Ariza, Guillermo;McConnell, Nicholas;Hulme, Christopher published 《One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines》. The research results were published in《Organic Letters》 in 2016.SDS of cas: 5805-39-0 The article conveys some information:
A cesium carbonate promoted three-component reaction of N-H containing heterocycles, primary or secondary amines, arylglyoxaldehydes, and anilines is reported. The key step involves a tandem sequence of N-1 addition of a heterocycle or an amine to preformed α-iminoketones, followed by an air- or oxygen-mediated oxidation to form α-oxo acetamidines. The scope of the reaction is broad, and this novel methodol. is applied toward the synthesis of various polycyclic heterocycles. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .
2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 SDS of cas: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem