Leal, Jorge;Santos, Lucia;Fernandez-Aroca, Diego M.;Cuevas, J. Vicente;Martinez, M. Angeles;Massaguer, Anna;Jalon, Felix A.;Ruiz-Hidalgo, M. Jose;Sanchez-Prieto, Ricardo;Rodriguez, Ana M.;Castaneda, Gregorio;Dura, Gema;Carrion, M. Carmen;Barrabes, Silvia;Manzano, Blanca R. published 《Effect of the aniline fragment in Pt(II) and Pt(IV) complexes as anti-proliferative agents. Standard reduction potential as a more reliable parameter for Pt(IV) compounds than peak reduction potential》. The research results were published in《Journal of Inorganic Biochemistry》 in 2021.Electric Literature of C13H11N3 The article conveys some information:
The problems of resistance and side effects associated with cisplatin and other chemotherapeutic drugs have boosted research aimed at finding new compounds with improved properties. The use of platinum(IV) prodrugs is one alternative, although there is some controversy regarding the predictive ability of the peak reduction potentials. In the work described here a series of fourteen chloride Pt(II) and Pt(IV) compounds was synthesized and fully characterized. The compounds contain different bidentate arylazole heterocyclic ligands. Their cytotoxic properties against human lung carcinoma (A549), human breast carcinoma (MCF7) and human colon carcinoma (HCT116 and HT29) cell lines were studied. A clear relationship between the type of ligand and the anti-proliferative properties was found, with the best results obtained for the Pt(II) compound that contains an aniline fragment, (13), thus evidencing a pos. effect of the NH2 group. Stability and aquation studies in DMSO, DMF and DMSO/water mixtures were carried out on the active complexes and an in-depth anal. of the two aquation processes, including DFT anal., of 13 was undertaken. It was verified that DNA was the target and that cell death occurred by apoptosis in the case of 13. Furthermore, the cytotoxic derivatives did not exhibit haemolytic activity. The reduction of the Pt(IV) compounds whose Pt(II) congeners were active was studied by several techniques. It was concluded that the peak reduction potential was not useful to predict the ability for reduction However, a correlation between the cytotoxic activity and the standard reduction potential was found.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.
2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Electric Literature of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem