Imidazole based anticancer drug find applications in cancer chemotherapy. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). HPLC of Formula: 3034-50-2.
Ding, Zhongpeng;Li, Feifei;Zhong, Changjiang;Li, Feng;Liu, Yuqian;Wang, Shixiao;Zhao, Jianchun;Li, Wenbao research published 《 Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer》, the research content is summarized as follows. To developed more potent anti-microtubule and cytotoxic derivatives, the co-crystal complexes of plinabulin derivatives (I) [R = H, Me, cyclopropyl, iso-Pr, tert-butyl; X = O, CO] and (II) [R1= 2-furyl, cyclohexyl, 2-benzoimidazolyl, etc.; X = O; R1= 5-methyl-2-furyl, 5-methoxymethyl-2-furyl; X = CO] were summarized and analyzed. The further modifications were performed the tert-Bu moiety or C-ring of imidazole-type derivatives to build a library of mols. through the introduction of different groups for novel skeletons. Our structure-activity relationship study indicated that compounds (II) [R1= 5-methoxymethyl-2-furyl, X = O] (IC50= 14.0 nM, NCI-H460) and [R1= 5-methoxymethyl-2-furyl, X = CO] (IC50= 2.9 nM, NCI-H460) with furan groups exhibited potent cytotoxic activities at the nanomolar level against various human cancer cell lines. In particular, the 5-Me or methoxymethyl substituent of furan group could replace the alkyl group of imidazole at the 5-position to maintain cytotoxic activity, contradicting previous reports that the tert-Bu moiety at the 5-position of imidazole was essential for the activity of such compounds Immunofluorescence assay indicated that compounds II [R1= 5-methoxymethyl-2-furyl, X = O, CO] could efficiently inhibited microtubule polymerization Overall, the novel furan-diketopiperazine-type derivatives I and II could be considered as a potential scaffold for the development of anti-cancer drugs.
3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, HPLC of Formula: 3034-50-2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem