Electric Literature of C13H11N3In 2021, Meng, Xiang-He;Wu, Dan-Ni;Zhang, Yu-Jia;Zhao, Yu-Long published 《PPTS-Catalyzed Bicyclization Reaction of 2-Isocyanobenzaldehydes with Various Amines: Synthesis of Diverse Fused Quinazolines》. 《Advanced Synthesis & Catalysis》published the findings. The article contains the following contents:
A PPTS (pyridinium p-toluenesulfonate)-catalyzed bicyclization reaction of 2-isocyanobenzaldehydes 2-NC-4-R-5-R1C6H2CHO (R = H, Br, OMe; R1 = H, Cl, F, OMe) as 1,5-dielectrophiles with various amines R2NH2 (R2 = 3-hydroxypropyl, 2-amino-4,5-difluorophenyl, 2-(1H-pyrrol-1-yl)benzen-1-yl, etc.) has been developed. The reaction not only provides a simple and efficient strategy for the assembly of structurally diverse fused quinazoline derivatives e.g., I from readily available substrates under metal-free and mild conditions in a single step with only water and hydrogen as the byproducts, but also opens the way to the application of o-formyl arylisocyanides in the synthesis of nitrogen-containing heterocycles e.g., I. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.
2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Electric Literature of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem