Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Product Details of C4H4N2O.
Cooper, Elizabeth N.;Averkiev, Boris;Day, Victor W.;Sues, Peter E. research published 《 Ring-Opening Polymerization of ε-Caprolactone Utilizing Aluminum Alkyl Complexes Bearing Dianionic Scorpionate Ligands》, the research content is summarized as follows. A series of eight scorpionate ligands (Ar)2CHR (1–4) were synthesized and coordinated to aluminum to produce Al(CH2CH3)((Ar)2CHR) (5–8), where R = CH2OCH3 (1 or 5), CH2N(CH3)2 (2 or 6), imidazole (3 or 7), or N-methylimidazole (4 or 8), and Ar = 2,4-dimethylphenol (a) or 2-tert-butyl-4-methylphenol (b). The bisphenol compounds were generated using a Friedel-Crafts alkylation reaction starting with com. available reagents. The scorpionate species were subsequently combined with triethylaluminum in order to probe the coordination geometries of 1–4. The resulting complexes 5–8 displayed distorted tetrahedral structures with the bisphenolate ligands acting as tridentate donors. The only exception was 5a, which formed phenolate bridged dimers in the solid state. Addnl., complexes 5–8 were active catalysts for the ring-opening polymerization of ε-caprolactone. The aluminum alkyl species affected this transformation both with and without the use of an alc. co-catalyst, but higher activities and cleaner activations were seen when 1 equivalent of iPrOH was employed. The less sterically hindered complexes with more weakly bound hemilabile “tails” showed the highest activities, with nearly 100% conversion after 1 h at 50°, and a catalyst loading of 1 mol %.
Product Details of C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem