Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Synthetic Route of 60-56-0.
Chen, Chen;Zhou, Peng;Wang, Rensong;Zhu, Fu;Sun, Wei;Shen, Weiliang;Xu, Hanhan;Hu, Guoxing;Hu, Yonghong;Yang, Wenge research published 《 Solubility determination and analysis of methimazole in different solvent systems at T = 278.15-323.15 K》, the research content is summarized as follows. Methimazole is a commonly used drugs for treatment of hyperthyroidism. Researching the solubility property of methimazole in multifarious solvent systems can be used for optimizing the purification process of methimazole in industry. In this study, the solubility properties of methimazole in twelve pure solvents (methanol, ethanol, 1-propanol, isopropanol, 1-butanol, isobutanol, 1,4-dioxane, Me acetate, acetonitrile, Et acetate, THF, acetone) and four binary mixed solvents (methanol + Et acetate, methanol + acetonitrile, methanol + isopropanol, methanol + Me acetate) were tested within 278.15 K to 323.15 K under 101.325 kPa. The results show that methimazole has the highest solubility in methanol and the smallest solubility in Et acetate. In addition, solubility is pos. correlated with temperature in pure solvents and mixed solvents. The XRD spectrum results show that the crystal form of methimazole before and after dissolving in twelve pure solvents do not change. The DSC test shows that the m.p. of methimazole is 417.27 K, and it is also proved that methimazole do not decompose before reaching the m.p. Herein, the Modified Apelblat model and Buchowski-Ksiazaczak λh model were used to fit the solubility data of methimazole in pure solvents. Jouyban-Acree model, CNIBS/R-K model and SUN model were used to fit the solubility data of methimazole in binary mixed solvents. The results show that Modified Apelblat model and CNIBS/R-K model have the best correlation with the solubility of methimazole. Anal. using the KAT-LSER model reveals that the influence of the interaction between part of the solvent and solute mol. on solubility The results show that the impact of dipolarity/polarizability is dominant.
Synthetic Route of 60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.
Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.
Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.
Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem