Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Product Details of C4H4N2O.
Bhattacharya, Sounak;Ray, Manabendra research published 《 Chiral resolution of 1-phenylethylamine in Schiff base form within a mixed ligand complex of Ni(II)》, the research content is summarized as follows. Racemic 1-phenylethylamine was converted to bidentate Schiff base ligand by condensing with imidazole-2-carboxaldehyde (rac-L2). The reaction between Ni(II)(ClO4)2, rac-L2 and another Schiff Base S-L1 (ratio:1:2:2) yielded crystals of fac-Δ-[Ni(S-L1)2(S-L2)](ClO4)2 (1). The ligand S-L1 is a condensation product of S-1-phenylethylamine and pyridine-2-carboxaldehyde. Enantiomeric excess (ee) of bulk crystals of 1 is ∼91%. The values were calculated from CD spectra and optical rotation experiments The ee measured on a non-crystalline form of 1, isolated by rapid precipitation, is ∼59%. The value supports the presence of chiral enhancement without the crystallization Compared to this, only 40-60% ee in crystals and 0% in precipitated form was achieved in the authors’ earlier report. Substituting rac-L2 with R-L2, in the reaction did not yield the [Ni(S-L1)2(R-L2)](ClO4)2 diastereoisomer. The solid from the reaction contains [Ni(S-L1)3](ClO4)2 complex among others. The enantiomer, fac-Δ-[Ni(R-L1)2(R-L2)](ClO4)2 (2), was synthesized and structurally characterized. Cyclic voltammetry (CV) of the complexes were analyzed for a probable method for electrochem. detection of enantiomers.
Product Details of C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem