Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Quality Control of 3034-50-2.
Bhaskaran, Ayana;Aitken, Heather M.;Xiao, Zeyun;Blyth, Mitchell;Nothling, Mitchell D.;Kamdar, Shashank;O′Mara, Megan L.;Connal, Luke A. research published 《 Enzyme inspired polymer functionalized with an artificial catalytic triad》, the research content is summarized as follows. At the heart of an enzyme′s structure is the active catalytic site, which, together with the surrounding amino-acid residues, tunes the substrate properties in the electrostatic microenvironment. Taking inspiration from nature′s catalytic triad, consisting of a hydroxyl group of a serine residue, an imidazole group of a histidine residue, and a carboxyl group of an aspartic acid, a polymer scaffolded enzyme mimic is incorporated with artificial catalytic triad units. It is demonstrated that controlling the local environment of the artificial triad affects catalytic activity. Compared to a water soluble artificial catalytic triad, enhanced esterolytic activity of p-nitrophenyl benzoate was observed for the polymeric catalyst possibly due to the hydrophobic microenvironment formed by the tertiary structure of the polymer backbone. The different environments were supported by mol. dynamics simulations. It is further demonstrated that the cross-linked catalytic triad functional polystyrene could be used as a reusable solid support catalyst for esterolysis.
3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Quality Control of 3034-50-2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem