The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives.
Bandopadhyay, Nilaj;Paramanik, Krishnendu;Mudi, Prafullya Kumar;Sarkar, Gayetri;Kotakonda, Muddukrishnaiah;Shit, Madhusudan;Biswas, Bhaskar;Sankar Das, Hari research published 《 A thiomethyl-substituted imidazolyl imine functionalized copper(II) complex: synthesis, structural characterization, phenoxazinone synthase mimics and biological activities》, the research content is summarized as follows. A cis-dichloro Cu(II) complex with a novel tridentate thiomethyl substituted imidazole based Schiff base ligand L, obtained from 2-methylthioaniline and 2-imidazolecarboxaldehyde, was synthesized and characterized by spectroscopic methods and x-ray crystallog. The crystal structure of the complex shows a distorted square-pyramidal environment around the Cu(II) center, coordinated by the tridentate ligand L and two cis-chloride ligands (axial and equatorial). The supramol. framework, connected through several intermol. noncovalent interactions in the crystal structure, was studied. The complex effectively shows phenoxazinone synthase-like activity (aerial oxidation of 2-aminophenol to 2-amino-phenoxazine-3-one) under ambient conditions with a high turnover number of 1.92 × 104 h-1. Further, the antimicrobial activity of the Cu(II) complex was examined against E. coli, Staphylococcus aureus and K. pneumoniae clin. microbial cultures, which imply its significant bactericidal property compared to the standard antibiotic agent ciprofloxacin. The anticancer activity of the Cu(II) complex was tested against the human colorectal adenocarcinoma (HT-29) cancerous cell line and it shows notable activity with an IC50 value of 125μg mL-1.
10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem